首页> 外文OA文献 >DeepConPred2: An Improved Method for the Prediction of Protein Residue Contacts
【2h】

DeepConPred2: An Improved Method for the Prediction of Protein Residue Contacts

机译:Deepconpred2:一种预测蛋白质残留触点的改进方法

代理获取
本网站仅为用户提供外文OA文献查询和代理获取服务,本网站没有原文。下单后我们将采用程序或人工为您竭诚获取高质量的原文,但由于OA文献来源多样且变更频繁,仍可能出现获取不到、文献不完整或与标题不符等情况,如果获取不到我们将提供退款服务。请知悉。

摘要

Information of residue-residue contacts is essential for understanding the mechanism of protein folding, and has been successfully applied as special topological restraints to simplify the conformational sampling in de novo protein structure prediction. Prediction of protein residue contacts has experienced amazingly rapid progresses recently, with prediction accuracy approaching impressively high levels in the past two years. In this work, we introduce a second version of our residue contact predictor, DeepConPred2, which exhibits substantially improved performance and sufficiently reduced running time after model re-optimization and feature updates. When testing on the CASP12 free modeling targets, our program reaches at least the same level of prediction accuracy as the best contact predictors so far and provides information complementary to other state-of-the-art methods in contact-assisted folding. Keywords: Residue contact prediction, Web server, Protein structure prediction, Contact-assisted folding, Machine learning
机译:残留物残留触点的信息对于了解蛋白质折叠机制是必不可少的,并且已成功应用于特殊的拓扑限制,以简化De Novo蛋白质结构预测的构象抽样。最近,蛋白质残留触点的预测经历了令人惊讶的快速进展,预测准确性在过去两年中令人印象深刻地逼近。在这项工作中,我们介绍了我们的Reside触点预测器的第二个版本,DeepConpred2,其在模型重新优化和特征更新之后表现出显着提高的性能和充分降低的运行时间。当在CASP12免费建模目标上进行测试时,我们的程序达到了至少与到目前为止的最佳接触预测器的预测精度等级,并提供与接触辅助折叠中的其他最先进方法互补的信息。关键词:残留接触预测,网页服务器,蛋白质结构预测,接触辅助折叠,机器学习

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
代理获取

客服邮箱:kefu@zhangqiaokeyan.com

京公网安备:11010802029741号 ICP备案号:京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有
  • 客服微信

  • 服务号