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New 2,4-Diamino-5-(2‘,5‘-substituted benzyl)pyrimidines as Potential Drugs against Opportunistic Infections of AIDS and Other Immune Disorders. Synthesis and Species-Dependent Antifolate Activity

机译：新的2,4-二氨基-5-（2'，5'-取代的苄基）嘧啶作为潜在药物的潜在药物，免受艾滋病和其他免疫障碍的机会性感染。合成和物种依赖性抗糖酸酯活性

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Andre Rosowsky; Ronald A. Forsch; Carol Hopkins Sibley; Clark B. Inderlied; Sherry F. Queener;
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年度 2004
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1. New 2,4-Diamino-5-(2',5'-substituted benzyl)pyrimidines as Potential Drugs against Opportunistic Infections of AIDS and Other Immune Disorders. Synthesis and Species-Dependent Antifolate Activity [J] . Andre Rosowsky, Ronald A. Forsch, Carol Hopkins Sibley, Journal of Medicinal Chemistry . 2004,第6期

机译：新的2,4-二氨基-5-（2'，5'-取代的苄基）嘧啶类药物可能对付艾滋病和其他免疫疾病的机会性感染。合成和物种依赖性抗叶酸活性
2. Further Studies on 2,4-Diamino-5-(2',5'-disubstituted benzyl)pyrimidines as Potent and Selective Inhibitors of Dihydrofolate Reductases from Three Major Opportunistic Pathogens of AIDS [J] . Andre Rosowsky, Ronald A. Forsch, Sherry F. Queener Journal of Medicinal Chemistry . 2003,第9期

机译：进一步研究2,4-二氨基-5-（2'，5'-二取代的苄基）嘧啶作为艾滋病三种主要机会病原体中二氢叶酸还原酶的强效和选择性抑制剂的进一步研究
3. Synthesis and antitumor activity of a novel series of 6-substituted pyrrolo[2,3-d]pyrimidines as potential nonclassical antifolates targeting both thymidylate and purine nucleotide biosynthesis [J] . Liu Yi, Zhang Chuang, Zhang Hongying, European Journal of Medicinal Chemistry: Chimie Therapeutique . 2015,第Null期

机译：一系列新型的6-取代的吡咯并[2,3-d]嘧啶类化合物作为潜在的非经典抗叶酸剂，靶向胸苷酸和嘌呤核苷酸的生物合成，其合成和抗肿瘤活性
4. Classical antifolates: Synthesis of 5-substituted, 6-substituted and 7-substituted pyrrolo[2,3-d]pyrimidines as targeted anticancer therapies [D] . Wang, Yiqiang 2013

机译：经典抗叶酸药物：5取代，6取代和7取代的吡咯并[2,3-d]嘧啶的合成作为靶向抗癌药物
5. Tumor Targeting with Novel 6-Substituted Pyrrolo 23-d Pyrimidine Antifolates with Heteroatom Bridge Substitutions Via Cellular Uptake by Folate Receptor α and the Proton-coupled Folate Transporter and Inhibition of De Novo Purine Nucleotide Biosynthesis [O] . Lalit K. Golani, Adrianne Wallace-Povirk, Siobhan M. Deis, -1

机译：通过叶酸受体α和质子偶联的叶酸转运蛋白通过细胞摄取和靶向新型6-取代的吡咯并23-d嘧啶类抗叶酸与杂原子桥取代并抑制De Novo嘌呤核苷酸的生物合成
6. Tumor Targeting with Novel 6-Substituted Pyrrolo 2,3-d Pyrimidine Antifolates with Heteroatom Bridge Substitutions via Cellular Uptake by Folate Receptor α and the Proton-Coupled Folate Transporter and Inhibition of de Novo Purine Nucleotide Biosynthesis [O] . Lalit K. Golani, Adrianne Wallace-Povirk, Siobhan M. Deis, 2016

机译：用叶酸受体α和质子偶联的叶酸转运蛋白通过细胞吸收与杂原子桥取代与杂原子桥取代的肿瘤靶向靶向杂膜取代，并抑制Novo嘌呤核苷酸生物合成

New 2,4-Diamino-5-(2‘,5‘-substituted benzyl)pyrimidines as Potential Drugs against Opportunistic Infections of AIDS and Other Immune Disorders. Synthesis and Species-Dependent Antifolate Activity

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