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The Analysis of the Urea Biosensors Using Different Sensing Matrices via Wireless Measurement System Microfluidic Measurement System

机译:通过无线测量系统和微流体测量系统使用不同传感矩阵的尿素生物传感器分析

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摘要

Two types of urea biosensors were integrated with a wireless measurement system and microfluidic measurement system. The two biosensors used were (i) a magnetic beads (MBs)-urease/graphene oxide (GO)/titanium dioxide (TiO2)-based biosensor and (ii) an MBs-urease/GO/ nickel oxide (NiO)-based biosensor, respectively. The wireless measurement system work exhibited the feasibility for the remote detection of urea, but it will require refinement and modification to improve stability and precision. The microchannel fluidic system showed the measurement reliability. The sensing properties of urea biosensors at different flow rates were investigated. From the measurement results, the decay of average sensitivity may be attributed to the induced vortex-induced vibrations (VIV) at the high flow rate. In the aspect of wireless monitoring, the average sensitivity of the urea biosensor based on MBs-urease/GO/NiO was 4.780 mV/(mg/dl) and with the linearity of 0.938. In the aspect of measurement under dynamic conditions, the average sensitivity of the urea biosensor based on MBs-urease/GO/NiO were 5.582 mV/(mg/dl) and with the linearity of 0.959. Both measurements performed NiO was better than TiO2 according to the comparisons.
机译:两种类型的尿素生物传感器与无线测量系统和微流体测量系统集成。使用的两种生物传感器是(i)磁性珠粒(MBS) - 尿氧化物/石墨烯(GO)/二氧化钛(TiO 2)被基于生物传感器和(II)的MBS - 脲酶/去/氧化镍(NIO)被基于生物传感器, 分别。无线测量系统工作表现出远程检测尿素的可行性,但它需要改进和修改来提高稳定性和精度。微通道流体系统显示了测量可靠性。研究了尿素生物传感器在不同流速下的感测性质。从测量结果,平均灵敏度的衰减可以归因于高流速的诱导涡旋诱导的振动(VIV)。在无线监测的方面,基于MBS-脲酶/去/ NIO的尿素生物传感器的平均敏感性为4.780mV /(Mg / dL),线性度为0.938。在动态条件下测量的方面,基于MBS - 脲酶/去/ NIO的尿素生物传感器的平均敏感性为5.582mV /(Mg / dL),线性度为0.959。根据比较,两种测量结果都比TiO2更好。

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