首页> 外文OA文献 >Enhanced G1 arrest and apoptosis via MDM4/MDM2 double knockdown and MEK inhibition in wild‑type TP53 colon and gastric cancer cells with aberrant KRAS signaling

【2h】

Enhanced G1 arrest and apoptosis via MDM4/MDM2 double knockdown and MEK inhibition in wild‑type TP53 colon and gastric cancer cells with aberrant KRAS signaling

机译：通过MDM4 / MDM2双敲击和伴随野生型TP53结肠和胃癌细胞的MDM4 / MDM2双敲击和MEK抑制增强了G1抑制和细胞凋亡，具有异常KRAS信号传导

代理获取

本网站仅为用户提供外文OA文献查询和代理获取服务，本网站没有原文。下单后我们将采用程序或人工为您竭诚获取高质量的原文，但由于OA文献来源多样且变更频繁，仍可能出现获取不到、文献不完整或与标题不符等情况，如果获取不到我们将提供退款服务。请知悉。

页面导航

著录项
引文网络
相似文献
相关主题

著录项

作者
Xiaoxuan Wang; Yoshiyuki Yamamoto; Mamiko Imanishi; Xiaochen Zhang; Masashi Sato; Akinori Sugaya; Mitsuaki Hirose; Shinji Endo; Yukikazu Natori; Toshikazu Moriwaki; Kenji Yamato; Ichinosuke Hyodo;
展开▼
作者单位

展开▼
年度 2021
总页数
原文格式 PDF
正文语种
中图分类

相似文献

外文文献
中文文献
专利

1. Knockdown of PAK4 or PAK1 inhibits the mroliferation of mutant KRAS colon cancer cells independently of RAF/MEK/ERK and PI3K/AKT signaling [J] . TabusaH., BrooksT., MasseyA.J. Molecular cancer research: MCR . 2013,第2期

机译：抑制PAK4或PAK1可以独立于RAF / MEK / ERK和PI3K / AKT信号传导抑制突变KRAS结肠癌细胞的增殖
2. MEK and TAK1 Regulate Apoptosis in Colon Cancer Cells with KRAS-Dependent Activation of Proinflammatory Signaling [J] . McNew Kelsey L., Whipple William J., Mehta Anita K., Molecular cancer research: MCR . 2016,第12期

机译：MEK和TAK1通过KRAS依赖性促炎信号激活调节结肠癌细胞凋亡
3. Combination PI3K/MEK inhibition promotes tumor apoptosis and regression in PIK3CA wild-type, KRAS mutant colorectal cancer [J] . RoperJ., SinnamonM.J., CoffeeE.M., Cancer letters . 2014,第2期

机译：PI3K / MEK组合抑制可促进PIK3CA野生型KRAS突变性结直肠癌的肿瘤凋亡和消退
4. RS-41, A multi-targeted kinase inhibitor, induces cell cycle arrest and apoptosis in P53 mutant and wild type models of upper gastrointestinal cancers. [D] . Visal, Tanvi. 2017

机译：RS-41是一种多靶点激酶抑制剂，在上消化道癌的P53突变型和野生型模型中诱导细胞周期停滞和凋亡。
5. Augmented antitumor activity of 5‐fluorouracil by double knockdown of MDM4 and MDM2 in colon and gastric cancer cells [O] . Mamiko Imanishi, Yoshiyuki Yamamoto, Xiaoxuan Wang, 2019

机译：MDM4和MDM2双重敲低在结肠和胃癌细胞中增强了5-氟尿嘧啶的抗肿瘤活性
6. Drug sensitivity profile of minor KRAS mutations in colorectal cancer using mix culture assay: The effect of AMG‑510, a novel KRAS G12C selective inhibitor, on colon cancer cells is markedly enhanced by the combined inhibition of MEK and BCL‑XL [O] . Masato Kitazawa, Yusuke Miyagawa, Makoto Koyama, 2021

机译：使用混合培养测定的小克拉斯突变的药物敏感性突变突变：通过MEK和BCL-XL的组合抑制显着提高了amg-510，新型KRAS G12C选择性抑制剂的效果显着提高了结肠癌细胞

Enhanced G1 arrest and apoptosis via MDM4/MDM2 double knockdown and MEK inhibition in wild‑type TP53 colon and gastric cancer cells with aberrant KRAS signaling

著录项

引文网络

相似文献

相关主题

期刊订阅