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Design of HIV-1 Protease Inhibitors with Pyrrolidinones and Oxazolidinones as Novel P1′-Ligands To Enhance Backbone-Binding Interactions with Protease: Synthesis, Biological Evaluation, and Protein−Ligand X-ray Studies

机译：用吡咯烷酮和恶唑烷酮的HIV-1蛋白酶抑制剂设计为新型P1'-配体，以增强与蛋白酶的骨架结合相互作用：合成，生物学评价和蛋白质 - 配体X射线研究

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Arun K. Ghosh; Sofiya Leshchenko-Yashchuk; David D. Anderson; Abigail Baldridge; Marcus Noetzel; Heather B. Miller; Yunfeng Tie; Yuan-Fang Wang; Yasuhiro Koh; Irene T. Weber; Hiroaki Mitsuya;
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1. Design of HIV-1 Protease Inhibitors with Pyrrolidinones and Oxazolidinones as Novel P1 '-Ligands To Enhance Backbone-Binding Interactions with Protease: Synthesis, Biological Evaluation, and Protein-Ligand X-ray Studies(infinity) [J] . Ghosh Arun K., Leshchenko-Yashchuk Sofiya, Anderson David D., Journal of Medicinal Chemistry . 2009,第13期

机译：以吡咯烷酮和恶唑烷酮为新型P1'-配体增强蛋白酶与骨干结合相互作用的HIV-1蛋白酶抑制剂的设计：合成，生物学评估和蛋白配体X射线研究（无穷大）
2. Design of HIV-1 Protease Inhibitors with Amino-bis-tetrahydrofuran Derivatives as P2-Ligands to Enhance Backbone-Binding Interactions: Synthesis, Biological Evaluation, and Protein Ligand X-ray Studies [J] . Ghosh Arun K., Martyr Cuthbert D., Osswald Heather L., Journal of Medicinal Chemistry . 2015,第17期

机译：HIV-1蛋白酶抑制剂与氨基双四氢呋喃衍生物作为P2-配体增强骨架结合相互作用的设计：合成，生物学评估和蛋白质配体X射线研究。
3. Design, synthesis, X-ray studies, and biological evaluation of novel macrocyclic HIV-1 protease inhibitors involving the P1′-P2′ ligands [J] . Arun K. Ghosh, W. Sean Fyvie, Margherita Brindisi, Bioorganic and Medicinal Chemistry Letters . 2017,第21期

机译：设计，合成，X射线研究和新型宏环HIV-1蛋白酶抑制剂的生物学评价，涉及P1'-P2'配体的蛋白质抑制剂
4. Coarse-grained and atomistic molecular dynamics study of the interactions between HIV-1 protease and its inhibitors [C] . Dechang Li, Ming S. Liu, Baohua Ji, International conference on fracture . 2013

机译：HIV-1蛋白酶与其抑制剂之间相互作用的粗粒和原子分子动力学研究
5. Methodologies for attaching polypyridyl ligands into amino acids and synthesis and biological evaluation of novel light activated peptidomimetic cysteine protease inhibitors caged by Ru(II)(bpy)2. [D] . Respondek, Tomasz. 2013

机译：将聚吡啶基配体连接到氨基酸上的方法，合成并被Ru（II）（bpy）2笼罩的新型光活化拟肽半胱氨酸蛋白酶抑制剂的生物学评估。
6. Design of HIV-1 Protease Inhibitors with Pyrrolidinones and Oxazolidinones as Novel P1’-Ligands to Enhance Backbone-binding interactions with Protease: Synthesis Biological Evaluation and Protein-ligand X-ray Studies [O] . Arun K. Ghosh, Sofiya Leshchenko-Yashchuk, David D. Anderson, -1

机译：HIV-1蛋白酶用吡咯烷酮和恶唑烷酮作为新型p1-配体抑制剂的设计以增强与蛋白酶骨架结合相互作用的合成生物学评价和蛋白 - 配体的X射线研究
7. Design, synthesis, X-ray studies, and biological evaluation of novel macrocyclic HIV-1 protease inhibitors involving the P1′-P2′ ligands [O] . Arun K. Ghosh, W. Sean Fyvie, Margherita Brindisi, 2017

机译：新型大环HIV-1蛋白酶抑制剂的设计，合成，X射线研究和涉及P1'-P2'配体的新型宏环HIV-1蛋白酶抑制剂的生物学评价

Design of HIV-1 Protease Inhibitors with Pyrrolidinones and Oxazolidinones as Novel P1′-Ligands To Enhance Backbone-Binding Interactions with Protease: Synthesis, Biological Evaluation, and Protein−Ligand X-ray Studies

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