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0007 Multiple-Ascending-Dose Study Of ACT-541468, A Novel Dual Orexin Receptor Antagonist: Characterization Of Its Multiple-Dose Pharmacokinetics, Pharmacodynamics, Safety, And Tolerability

机译：0007 ACT-541468的多次上升剂量研究，一种新型双羊酸蛋白受体拮抗剂：其多剂量药代动力学，药效学，安全性和耐受性的表征

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C Muehlan; S Brooks; R Zuiker; J van Gerven; J Dingemanse;
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1. Clinical pharmacology of the dual orexin receptor antagonist ACT-541468 in elderly subjects: Exploration of pharmacokinetics, pharmacodynamics and tolerability following single-dose morning and repeated-dose evening administration [J] . Muehlan Clemens, Boehler Margaux, Brooks Sander, Journal of psychopharmacology . 2020,第3期

机译：老年人双欧洲受体拮抗剂ACT-541468的临床药理学：单剂量早晨和重复剂量晚期管理后药代动力学，药效学和耐受性的探索
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机译：新型双重食欲素受体拮抗剂SB-649868的安全性，耐受性，药代动力学和药效动力学的第一阶段研究
3. Single- and multiple-dose tolerability, safety, pharmacokinetics, and pharmacodynamics of the dual endothelin receptor antagonist aprocitentan in healthy adult and elderly subjects [J] . Patricia N Sidharta, Meggane Melchior, Martin K Kankam, Drug Design, Development and Therapy . 2019,第InaProgress期

机译：双重内皮素受体拮抗剂aprocitentan在健康成人和老年受试者中的单剂量和多剂量耐受性，安全性，药代动力学和药效学
4. Safety, tolerability, pharmacodynamics and pharmacokinetics following single subcutaneous dosesof a teverelix depot formulation in healthy male volunteers [C] . C. MacLean, F. Larsen, R. Piechatzek, Annual meeting exposition of the Controlled Release Society . 2005

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5. Characterization of renal anionic drug transport capacity in kidney transplant recipients with persistent BK viremia: Pharmacokinetic and pharmacodynamic studies of cidofovir. [D] . Momper, Jeremiah D. 2011

机译：持续性BK病毒血症的肾脏移植受者中肾脏阴离子药物转运能力的表征：西多福韦的药代动力学和药效学研究。
6. Single- and multiple-dose tolerability safety pharmacokinetics and pharmacodynamics of the dual endothelin receptor antagonist aprocitentan in healthy adult and elderly subjects [O] . Patricia N Sidharta, Meggane Melchior, Martin K Kankam, 2019

机译：双重内皮素受体拮抗剂aprocitentan在健康成人和老年受试者中的单剂量和多剂量耐受性安全性药代动力学和药效学
7. The Use of Physiology-Based Pharmacokinetic and Pharmacodynamic Modeling in the Discovery of the Dual Orexin Receptor Antagonist ACT-541468 [O] . Alexander Treiber, Ruben de Kanter, Catherine Roch, 2017

机译：使用生理学的药代动力学和药物动力学建模在双奥克替素受体拮抗剂ACT-541468发现中的发现

0007 Multiple-Ascending-Dose Study Of ACT-541468, A Novel Dual Orexin Receptor Antagonist: Characterization Of Its Multiple-Dose Pharmacokinetics, Pharmacodynamics, Safety, And Tolerability

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