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A phase I, pharmacokinetic, and pharmacodynamic evaluation of the DNA methyltransferase inhibitor 5-fluoro-2′-deoxycytidine, administered with tetrahydrouridine

机译：DNA甲基转移酶抑制剂5-氟-2'-脱氧胞苷的I相，药代动力学和药效学评价，与四氢尿苷施用

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Edward M. Newman; Robert J. Morgan; Shivaani Kummar; Jan H. Beumer; M. Suzette Blanchard; Christopher Ruel; Anthony B. El-Khoueiry; Mary I. Carroll; Jessie M. Hou; Chun Li; Heinz J. Lenz; Julie L. Eiseman; James H. Doroshow;
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1. A phase I, pharmacokinetic, and pharmacodynamic evaluation of the DNA methyltransferase inhibitor 5-fluoro-2'-deoxycytidine, administered with tetrahydrouridine [J] . Newman Edward M., Morgan Robert J., Kummar Shivaani, Cancer chemotherapy and pharmacology. . 2015,第3期

机译：给予四氢尿苷的DNA甲基转移酶抑制剂5-氟-2'-脱氧胞苷I期，药代动力学和药效学评估
2. Concentrations of the DNA methyltransferase inhibitor 5-fluoro-2'-deoxycytidine (FdCyd) and its cytotoxic metabolites in plasma of patients treated with FdCyd and tetrahydrouridine (THU). [J] . Beumer JH, Parise RA, Newman EM, Cancer chemotherapy and pharmacology. . 2008,第2期

机译：用FdCyd和四氢尿苷（THU）治疗的患者血浆中DNA甲基转移酶抑制剂5-氟-2'-脱氧胞苷（FdCyd）及其细胞毒性代谢产物的浓度。
3. Concentrations of the DNA methyltransferase inhibitor 5-fluoro-2′-deoxycytidine (FdCyd) and its cytotoxic metabolites in plasma of patients treated with FdCyd and tetrahydrouridine (THU) [J] . Jan H. Beumer, Robert A. Parise, Edward M. Newman, Cancer Chemotherapy and Pharmacology . 2008,第2期

机译：用FdCyd和四氢尿苷（THU）治疗的患者血浆中DNA甲基转移酶抑制剂5-氟-2'-脱氧胞苷（FdCyd）及其细胞毒性代谢产物的浓度
4. CLINICAL CONTROL OF PLEUROPNEUMONIA WITH FEED-ADMINISTERED CHLORTETRACYCLINE OR OXYTETRACYCLINE: A PHARMACOKINETIC-PHARMACODYNAMIC EVALUATION [C] . J.R.E. del Castillo, G.P. Martineau, M.R. Hannon, Congress of the International Pig Veterinary Society . 2000

机译：具有饲料碳化碳或氧化素的胸膜炎胸膜炎的临床控制：药代动力学 - 药效学评估
5. Preclinical evaluation of 5-aza-2'-deoxycytidine, an inhibitor of DNA methylation, for therapy of breast cancer. [D] . Bovenzi, Veronica. 2001

机译：DNA甲基化抑制剂5-氮杂2'-脱氧胞苷的临床前评价，用于乳腺癌的治疗。
6. A phase I pharmacokinetic and pharmacodynamic evaluation of the DNA methyltransferase inhibitor 5-fuoro-2′-deoxycytidine administered with tetrahydrouridine [O] . Edward M. Newman, Robert J. Morgan, Shivaani Kummar, -1

机译：给予四氢尿苷的DNA甲基转移酶抑制剂5-fuoro-2-脱氧胞苷I期药代动力学和药效学评估
7. A Phase 1 dose-escalation study to evaluate safety, pharmacokinetics and pharmacodynamics of AsiDNA, a first-in-class DNA repair inhibitor, administered intravenously in patients with advanced solid tumours [O] . Christophe Le Tourneau, Jean-Pierre Delord, Nuria Kotecki, 2020

机译：1期剂量升级研究，以评估ASIDNA的安全性，药代动力学和药效学，一流的DNA修复抑制剂，静脉注射治疗晚期实体肿瘤的患者

A phase I, pharmacokinetic, and pharmacodynamic evaluation of the DNA methyltransferase inhibitor 5-fluoro-2′-deoxycytidine, administered with tetrahydrouridine

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