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Optimization of Primary Drying Condition for Pharmaceutical Lyophilization Using a Novel Simulation Program with a Predictive Model for Dry Layer Resistance

机译：用新型仿真程序利用具有预测模型的干燥层抗性的药物冻干初级干燥条件优化

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Tatsuhiro Kodama; Hiroyuki Sawada; Hiroshi Hosomi; Masahito Takeuchi; Naoki Wakiyama; Etsuo Yonemochi; Katsuhide Terada;
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1. Optimization of Primary drying Condition for Pharmaceutical Lyophilization Using a Novel Simulation Program with a Predictive model for dry Layer Resistance [J] . Tatsuhiro Kodama, Hiroyuki Sawada, Hiroshi Hosomi, Chemical and Pharmaceutical Bulletin . 2014,第2期

机译：新型冻干阻力预测模型的模拟程序优化药物冻干的主要干燥条件
2. Optimization of Primary Drying Condition for Pharmaceutical Lyophilization Using a Novel Simulation Program with a Predictive Model for Dry Layer Resistance [J] . Chemical and Pharmaceutical Bulletin . 2014,第2期

机译：新型冻干阻力预测模型模拟程序优化药物冻干的主要干燥条件
3. Determination for dry layer resistance of sucrose under various primary drying conditions using a novel simulation program for designing pharmaceutical lyophilization cycle. [J] . Tatsuhiro Kodama, Hiroyuki Sawada, Hiroshi Hosomi, International Journal of Pharmaceutics . 2013,第1a2期

机译：使用设计药物冻干循环的新型模拟程序，在各种初级干燥条件下确定蔗糖的干层抗性。
4. OPTIMAL CONTROL OF THE PRIMARY AND SECONDARY DRYING STAGES OF THE FREEZE DRYING OF PHARMACEUTICALS IN VIALS [C] . A. I. Liapis, R. Bruttini, H. Sadikoglu Proceedings of the 12th international drying symposium IDS2000 . 2000

机译：药瓶冷冻干燥的主要和次要干燥阶段的最佳控制
5. Tool life and flank wear modeling of physical vapour deposited titanium aluminum nitride/titanium nitride multilayer coated carbide inserts when end milling 4340 steel under dry and semi-dry cutting conditions [D] . Chakraborty, Pinaki 2007

机译：在干式和半干式切削条件下端铣4340钢时，物理气相沉积的氮化钛铝/氮化钛多层涂层硬质合金刀片的刀具寿命和侧面磨损模型
6. Finite Element Method (FEM) Modeling of Freeze-drying: Monitoring Pharmaceutical Product Robustness During Lyophilization [O] . Xiaodong Chen, Vikram Sadineni, Mita Maity, 2015

机译：冷冻干燥的有限元方法（FEM）建模：冻干过程中监测药品的坚固性
7. ABSTRACTudThe purpose of this research is to obtain an optimal formulations of Black mulberry leaves dried noodle product by using Design Expert Application with Design Mixture D-optimal method.udThis research was done with two phases. The preliminary procedures research is to determine levels of antioxidant activity, chlorophyll content, and the levels of tannin that was contained in black mulberry leaves, the black mulberry leaf flour, a pare fruits, and pare flour. Primary research is to determine the best formulation by using a Mixture Design Expert Design D-optimal method, for a purpose is to optimized the Black mulberry leaf dry noodle. Responses in this studies are a chemical analysis response by using a crude fiber analysis and protein analysis. Physical response is water absorption. Sensory response are color, flavor, and odor.udBlack mulberry leaves dried noodles was made from wheat flour, black mulberry leaf flour, and pare flour, other materials such as an eggs, water, salt, and sodium bicarbonate, of the 16 formulations that has offered to produce an optimal formulation based on desirability which contains 39.69 Flour,14.25 Black Mulberry Leaves flour, 3.06 Pare fruit and flour amounted, and other materials are 30 water, 10 eggs, 2 salt, and 1 sodium bicarbonate. The formulation has been result by program 11,05 crude fiber content, 12.93 protein, 274.31 water absorption, 4,31 for color attribute, 3,87 for taste attribute, and 3,71 for aroma attribute.ududKeyword: Black mulberry leaf dried noodles, optimization. [O] . Leti Nurlatifah Alumni, Yudi Garnida DS, Tantan Widiantara DS 2017

机译：抽象 ud本研究的目的是通过使用带有Design Mixture D-最优方法的Design Expert Application获得黑桑叶干面条产品的最佳配方。 ud这项研究分两个阶段进行。初步程序研究是确定抗氧化剂活性，叶绿素含量以及黑桑叶，黑桑叶粉，果皮和果皮中所含单宁的含量。首要研究是通过使用Mixture Design Expert Design D-optimal方法确定最佳配方，目的是优化黑桑叶干面条。本研究中的反应是通过使用粗纤维分析和蛋白质分析进行的化学分析反应。物理反应是吸水。感官反应是颜色，味道和气味。黑桑叶干面条由小麦粉，黑桑叶粉和削皮粉，鸡蛋，水，盐和碳酸氢钠等其他材料制成，这16种配方可根据需要提供最佳配方其中包含39.69％的面粉，14.25％的黑桑叶面粉，3.06％的去皮水果和面粉，其他材料是30％的水，10％的鸡蛋，2％的盐和1％的碳酸氢钠。该配方是通过程序11,05％的粗纤维含量，12.93％的蛋白质，274.31％的吸水率，4.31的颜色属性，3,87的味道属性和3,71的芳香属性得出的。 ud关键字：黑桑叶干面条，优化。
8. Simulation and Optimization of Hot Dry Rock Geothermal Energy Conversion Systems: Process Conditions and Economics [R] . Tester, J. W. 1978

机译：热干岩地热能转换系统的模拟与优化：工艺条件与经济学

Optimization of Primary Drying Condition for Pharmaceutical Lyophilization Using a Novel Simulation Program with a Predictive Model for Dry Layer Resistance

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