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Preliminary results from a phase 1b double-blind study to assess the safety, tolerability and efficacy of intra-articular administration of resiniferatoxin or placebo for the treatment of moderate to severe pain due to osteoarthritis of the knee

机译：1B阶段双盲研究的初步结果评估关节植物毒素或安慰剂的关节内施用的安全性，耐受性和疗效，以治疗膝关节骨关节炎的中度至严重疼痛

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D. Leiman; H. Minkowitz; R.C. Levitt; D. Solanki; D. Horn; D. Janfaza; D. Sarno; N. Albores-Ibarra; X. Bai; K. Takeshita; T. Zhao; C.-W. Lu; P. Bharathi; J. Ahern; S. Klincewicz; S.S. Nedeljkovic;
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1. PRELIMINARY RESULTS FROM A PHASE 1B DOUBLE-BLIND STUDY TO ASSESS THE SAFETY, TOLERABILITY AND EFFICACY OF INTRA-ARTICULAR ADMINISTRATION OF RESINIFERATOXIN OR PLACEBO FOR THE TREATMENT OF MODERATE TO SEVERE PAIN DUE TO OSTEOARTHRITIS OF THE KNEE [J] . Osteoarthritis and cartilage . 2020,第Suppla1期

机译：1B期双盲研究的初步结果，以评估关节内施用树脂植物毒素或安慰剂的安全性，耐受性和疗效，以治疗膝关节骨关节炎的中度至严重疼痛
2. A Randomized, Double-Blind, Placebo-Controlled, Phase II Study Assessing Safety, Tolerability, and Efficacy of Bryostatin in the Treatment of Moderately Severe to Severe Alzheimer's Disease [J] . Farlow Martin R., Thompson Richard E., Wei Lee-Jen, Journal of Alzheimer's disease: JAD . 2019,第2期

机译：随机，双盲，安慰剂控制，II期研究评估苔藓抑素治疗中度严重至严重阿尔茨海默病的安全性，耐受性和疗效
3. A Phase IIIb, Multicentre, Randomised, Parallel-Group, Placebo-Controlled, Double-Blind Study to Investigate the Efficacy and Safety of OROS Hydromorphone in Subjects with Moderate-to-Severe Chronic Pain Induced by Osteoarthritis of the Hip or the Knee [J] . JozefVojta??ák, AdamJacobs, LeonieRynn, Pain Research and Treatment . 2011,第1期

机译：IIIb期，多中心，随机，平行组，安慰剂对照，双盲研究旨在研究OROS氢吗啡酮在中度至重度由髋或膝骨关节炎引起的中度至重度慢性疼痛患者中的疗效和安全性
4. Study of Efficacy and Safety of Willow Bark Extract (Assalix) in Treatment of Chronic Low Back Pain in Patients of Different Age with Osteochondrosis [C] . V.V. Povoroznyuk, T.A. Karasevskaya International Pain Clinic Congress . 2008

机译：柳树皮提取物（Assalix）治疗不同年龄患者慢性低腰疼痛的疗效和安全性研究
5. A Phase 1B, Double-blind, Placebo-controlled, Parallel-group, Multi-dose Study of the Pharmacodynamics of NGM282 on Colonic Transit, Bile Acid Homeostasis and Fecal Fat in Subjects with Functional Constipation [D] . Oduyebo, Ibironke. 2018

机译：1B，双盲，安慰剂控制，并行组，NGM282对结肠转运，胆汁酸痛和患者功能性便秘的粪便脂肪的药物动力学的多剂量研究
6. A Randomized Double-Blind Placebo-Controlled Phase II Study Assessing Safety Tolerability and Efficacy of Bryostatin in the Treatment of Moderately Severe to Severe Alzheimer’s Disease [O] . Martin R. Farlow, Richard E. Thompson, Lee-Jen Wei, -1

机译：一项随机双盲安慰剂对照的II期临床研究评估Bryostatin治疗中度至重度阿尔茨海默氏病的安全性耐受性和有效性
7. A Randomized, Double-Blind, Placebo-Controlled, Phase II Study Assessing Safety, Tolerability, and Efficacy of Bryostatin in the Treatment of Moderately Severe to Severe Alzheimer’s Disease [O] . Martin R. Farlow, Richard E. Thompson, Lee-Jen Wei, 2019

机译：随机，双盲，安慰剂控制，期II研究评估苔藓醛酸的安全性，耐受性和功效治疗中度严重至严重的Alzheimer病

Preliminary results from a phase 1b double-blind study to assess the safety, tolerability and efficacy of intra-articular administration of resiniferatoxin or placebo for the treatment of moderate to severe pain due to osteoarthritis of the knee

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