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Binding and functional profiling of antibody mutants guides selection of optimal candidates as antibody drug conjugates

机译：抗体突变体的结合和功能性分析指导选择最佳候选者作为抗体药物缀合物

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John C. Zwaagstra; Traian Sulea; Jason Baardsnes; Stevo Radinovic; Yuneivy Cepero-Donates; Alma Robert; Maureen D. O’Connor-McCourt; Ilia A. Tikhomirov; Maria Luz. Jaramillo;
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1. Binding and functional profiling of antibody mutants guides selection of optimal candidates as antibody drug conjugates [J] . John C. Zwaagstra, Traian Sulea, Jason Baardsnes, PLoS One . 2019,第12期

机译：抗体突变体的结合和功能性分析指导选择最佳候选物作为抗体药物缀合物
2. A Preclinical Safety Testing Algorithm for Antibody Drug Conjugate (ADC) Lead Optimization and Candidate Selection [J] . Lee D. W., Stagg N., Vuillemenot B., International journal of toxicology . 2018,第1期

机译：抗体药物缀合物（ADC）铅优化和候选选择的临床安全测试算法
3. Current strategies in antibody engineering: Fc engineering and pH-dependent antigen binding, bispecific antibodies and antibody drug conjugates [J] . Karen J. Vincent, Mauro Zurini Biotechnology Journal: Healthcare,Nutrition,Technology . 2012,第12期

机译：抗体工程的当前策略：Fc工程和pH依赖性抗原结合，双特异性抗体和抗体药物偶联物
4. Developability Profiling: Guiding Lead Selection of Candidate Therapeutic Antibodies [C] . Pierre Scotney, Peter Schmidt, Shirley Taylor, PEGS . 2015

机译：开发性分析：指导候选治疗抗体的引导选择
5. Investigating the Pharmacokinetics and Pharmacodynamics of Antibody-Drug Conjugates, T Cells and Bispecific Antibodies [D] . Khot, Antari . 2020

机译：调查抗体 - 药物缀合物，T细胞和双特异性抗体的药代动力学和药效学
6. Binding and functional profiling of antibody mutants guides selection of optimal candidates as antibody drug conjugates [O] . John C. Zwaagstra, Traian Sulea, Jason Baardsnes, 2019

机译：抗体突变体的结合和功能性分析指导选择最佳候选者作为抗体药物缀合物
7. Rapid conjugation of antibodies to toxins to select candidates for the development of anticancer Antibody-Drug Conjugates (ADCs) [O] . Ricarda M. Hoffmann, Silvia Mele, Anthony Cheung, 2020

机译：抗体对毒素的快速缀合选择抗癌抗体 - 药物缀合物的候选物（ADC）

Binding and functional profiling of antibody mutants guides selection of optimal candidates as antibody drug conjugates

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