Enantioselective Claisen Rearrangements: Development of a First Generation Asymmetric Acyl-Claisen Reaction

摘要

The development of an enantioselective catalytic Claisenudrearrangement remains an important yet elusive goal in chemical synthesis. With this objective in mind, we recently reported the acyl-Claisen rearrangement, a Lewis acid-catalyzed variant of the Bellus reaction that utilizes acid chlorides and allylic amines in the stereoselective synthesis of ɑ,β-disubstituted-y,δ-unsaturated carbonyls (eq 1).