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Deoxyguanosine enhances the cytotoxicity of the topoisomerase I inhibitor camptothecin by reducing the repair of double-strand breaks induced in replicating DNA

机译：脱氧核苷酸通过减少复制DNA诱导的双链断裂的修复来增强拓扑异构酶I抑制剂喜树碱的细胞毒性

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S. Squires; A.J. Ryan; H.L. Strutt; P.J. Smith; R.T. Johnson;
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年度 1991
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1. p21CDKN1A allows the repair of replication-mediated DNA double-strand breaks induced by topoisomerase I and is inactivated by the checkpoint kinase inhibitor 7-hydroxystaurosporine [J] . T Furuta, R L Hayward, L-H Meng, Oncogene . 2006,第20期

机译：p21CDKN1A可以修复由拓扑异构酶I诱导的复制介导的DNA双链断裂，并被检查点激酶抑制剂7-hydroxystaurosporine灭活
2. Camptothecin, a specific inhibitor of type I DNA topoisomerase, induces DNA breakage at replication forks. [J] . K Avemann, R Knippers, T Koller, Molecular and Cellular Biology . 1988,第8期

机译：喜树碱是I型DNA拓扑异构酶的特异性抑制剂，可在复制叉处诱导DNA断裂。
3. F 11782, a novel catalytic inhibitor of topoisomerases I and II, induces atypical, yet cytotoxic DNA double-strand breaks in CHO-K1 cells. [J] . Barret JM, Etievant C, Baudouin C, Anticancer Research: International Journal of Cancer Research and Treatment . 2002,第1Appa期

机译：F 11782是拓扑异构酶I和II的新型催化抑制剂，可在CHO-K1细胞中诱导非典型但具有细胞毒性的DNA双链断裂。
4. The protective effect of reduced glutathione oncadmium-induced DNA double-strand breaks [C] . Xueyuan Li, Weiwei Li, Jinxin Kong, International Conference on Human Health and Medical Engineering. . 2014

机译：降脂谷胱甘肽诱导的DNA双链断裂的保护作用
5. Repair of P element-induced DNA double-strand breaks. [D] . Weinert, Brian Tate. 2006

机译：修复P元素诱导的DNA双链断裂。
6. Camptothecin a specific inhibitor of type I DNA topoisomerase induces DNA breakage at replication forks. [O] . K Avemann, R Knippers, T Koller, 1988

机译：喜树碱一种I型DNA拓扑异构酶的特异性抑制剂在复制叉处诱导DNA断裂。
7. p21CDKN1A allows the repair of replication-mediated DNA double-strand breaks induced by topoisomerase I and is inactivated by the checkpoint kinase inhibitor 7-hydroxystaurosporine [O] . T Furuta, R L Hayward, L-H Meng, 2006

机译：P21CDKN1A允许修复由拓扑异构酶I诱导的复制介导的DNA双链断裂，并通过检查点激酶抑制剂7-羟基胱孢子素灭活

Deoxyguanosine enhances the cytotoxicity of the topoisomerase I inhibitor camptothecin by reducing the repair of double-strand breaks induced in replicating DNA

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