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Initial Cross-Over Test of A Positive Allosteric Modulator of Alpha-7 Nicotinic Receptors to Aid Cessation in Smokers With Or Without Schizophrenia

机译：α-7烟碱受体阳性变构调节剂的初始交叉试验，有助于或没有精神分裂症的吸烟者戒烟

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Kenneth A Perkins; K N Roy Chengappa; Joshua L Karelitz; Margaret C Boldry; Valerie Michael; Taylor Herb; Jessica Gannon; Jaspreet Brar; Lisa Ford; Stefanie Rassnick; Darlene H Brunzell;
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1. Discovery and optimization of Lu AF58801, a novel, selective and brain penetrant positive allosteric modulator of alpha-7 nicotinic acetylcholine receptors: Attenuation of subchronic phencyclidine (PCP)-induced cognitive deficits in rats following oral administration [J] . EskildsenJ., RedrobeJ.P., SamsA.G., Bioorganic and Medicinal Chemistry Letters . 2014,第1期

机译：发现和优化Lu AF58801，一种新型的，选择性的，脑渗透性的α-7烟碱乙酰胆碱受体正变构调节剂：口服后大鼠亚慢性苯环利定（PCP）引起的认知功能障碍的减轻
2. Positive allosteric modulation of alpha-7 nicotinic receptors promotes cell death by inducing Ca2+ release from the endoplasmic reticulum [J] . Guerra-Alvarez Maria, Moreno-Ortega Ana J., Navarro Elisa, Journal of Neurochemistry: Offical Journal of the International Society for Neurochemistry . 2015,第3期

机译：α-7烟碱样受体的正构构调节通过诱导内质网释放Ca2 +促进细胞死亡。
3. Positive allosteric modulators of alpha 7 nicotinic acetylcholine receptors reverse ketamine-induced schizophrenia-like deficits in rats [J] . Nikiforuk Agnieszka, Kos Tomasz, Holuj Maigorzata, Neuropharmacology . 2016,第Null期

机译：α7烟碱乙酰胆碱受体的正构构调节剂逆转氯胺酮诱导的大鼠精神分裂症样缺陷
4. IDENTIFICATION OF NADPH-INDEPENDENT GSH CONJUGATES OF ACETYLENE-CONTAINING POSITIVE ALLOSTERIC MODULATORS OF METABOTROPIC GLUTAMATE RECEPTOR SUBTYPE 5 [C] . Xiaoliang Zhuo, Xiaohua Huang, Andrew Degnan, ASMS Conference on Mass Spectrometry and Allied Topics . 2014

机译：鉴定含乙炔谷氨酸受体亚型5的含乙炔的阳性变构调节剂的NADPH-无关的GSH缀合物
5. Identification and characterization of a novel positive allosteric modulator of alpha 7 nicotinic acetylcholine receptors with therapeutic potential in schizophrenia [D] . Ng, Herman Jen 2007

机译：新型精神病性精神分裂症的α7烟碱乙酰胆碱受体的新型变构调节剂的鉴定与表征
6. Initial Cross-Over Test of A Positive Allosteric Modulator of Alpha-7 Nicotinic Receptors to Aid Cessation in Smokers With Or Without Schizophrenia [O] . Kenneth A Perkins, K N Roy Chengappa, Joshua L Karelitz, 2018

机译：Alpha-7烟碱受体阳性变构调节剂对有或没有精神分裂症的吸烟者戒烟的初始交叉试验
7. Expeditious Synthesis, Enantiomeric Resolution, and Enantiomer Functional Characterization of (4-(4-Bromophenyl)-3a,4,5,9b-tetrahydro-3H-cyclopentacquinoline-8-sulfonamide (4BP-TQS): An Allosteric Agonist-Positive Allosteric Modulator of α7 Nicotinic Acetylcholine Receptors [O] . Ganesh A. Thakur, Abhijit R. Kulkarni, Jeffrey R. Deschamps, 2013

机译：迅速的合成，对映体分辨率和映体功能表征（4-（4-溴苯基）-3a，4,5,9b-四氢-3H-环戊基c喹啉-8-磺酰胺（4bp-tqs）：一个变构激动剂 - α7烟碱乙酰胆碱受体的阳性变形调节剂

Initial Cross-Over Test of A Positive Allosteric Modulator of Alpha-7 Nicotinic Receptors to Aid Cessation in Smokers With Or Without Schizophrenia

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