首页> 外文OA文献 >KAE609 (Cipargamin), a New Spiroindolone Agent for the Treatment of Malaria: Evaluation of the Absorption, Distribution, Metabolism, and Excretion of a Single Oral 300-mg Dose of 14CKAE609 in Healthy Male Subjects

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KAE609 (Cipargamin), a New Spiroindolone Agent for the Treatment of Malaria: Evaluation of the Absorption, Distribution, Metabolism, and Excretion of a Single Oral 300-mg Dose of 14CKAE609 in Healthy Male Subjects

机译：KAE609（CIPARGAMIN），一种用于治疗疟疾的新螺茚酒代理：评估吸收，分布，新陈代谢和在健康男性受试者中的单个口服300mg剂量的14C KAE609的影响

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S.-E. W. Huskey; C.-q. Zhu; A. Fredenhagen; J. Kuhnol; A. Luneau; Z. Jian; Z. Yang; Z. Miao; F. Yang; J. P. Jain; G. Sunkara; J. B. Mangold; D. S. Stein;
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1. KAE609 (Cipargamin), a New Spiroindolone Agent for the Treatment of Malaria: Evaluation of the Absorption, Distribution, Metabolism, and Excretion of a Single Oral 300-mg Dose of [C-14]KAE609 in Healthy Male Subjects [J] . Huskey Su-Er W., Zhu Chun-qi, Fredenhagen Andreas, Drug Metabolism and Disposition: The Biological Fate of Chemicals . 2016,第5期

机译：KAE609（西帕加明），一种新的螺丙醇酮药物治疗疟疾：评价健康男性受试者中口服一次300 mg剂量的[C-14] KAE609的吸收，分布，代谢和排泄
2. Absorption, Distribution, and Excretion of the Investigational Agent Orteronel (TAK-700) in Healthy Male Subjects: A Phase 1, Open-Label, Single-Dose Study. [J] . Ajit Suri, Sandeepraj Pusalkar, Yuexian Li, Clinical pharmacology in drug development . 2016,第3期

机译：研究剂Orteronel（TAK-700）在健康男性受试者中的吸收，分布和排泄：阶段1，开放标签，单剂量研究。
3. An open-label, single-dose, phase 1 study of the absorption, metabolism and excretion of quizartinib, a highly selective and potent FLT3 tyrosine kinase inhibitor, in healthy male subjects, for the treatment of acute myeloid leukemia [J] . Sanga Madhu, James Joyce, Marini Joseph, Xenobiotica: the fate of foreign compounds in biological systems . 2017,第1a12期

机译：Quizartinib的吸收，代谢和排泄的开放标签，单剂量，相1研究，适用于健康男性受试者的高度选择性和有效的FLT3酪氨酸激酶抑制剂，用于治疗急性髓性白血病
4. The role of transporters in the absorption, distribution, metabolism and excretion (ADME) of orally administered drugs. [D] . Shugarts, Sarah B. 2010

机译：转运蛋白在口服药物吸收，分布，代谢和排泄（ADME）中的作用。
5. A First-in-Human Randomized Double-Blind Placebo-Controlled Single- and Multiple-Ascending Oral Dose Study of Novel Antimalarial Spiroindolone KAE609 (Cipargamin) To Assess Its Safety Tolerability and Pharmacokinetics in Healthy Adult Volunteers [O] . F. Joel Leong, Ruobing Li, Jay Prakash Jain, 2014

机译：新型抗疟药螺螺旋吲哚酮KAE609（西帕加敏）的首次人类随机双盲安慰剂对照单次和多次递增口服剂量研究以评估其在健康成人志愿者中的安全性耐受性和药代动力学
6. Evaluation of the Absorption, Metabolism, and Excretion of a Single Oral 1 mg Dose of Tropifexor in Healthy Male Subjects and the Concentration Dependency of Tropifexor Metabolism [O] . Lydia Wang-Lakshman, Zhuang Miao, Lai Wang, 2021

机译：评估健康男性对象的单个口腔1mg rootifexor的吸收，新陈代谢和排泄和热引擎代谢的浓度依赖性
7. Absorption, Distribution, Excretion, and Metabolism of a Single Oral Dose of o-Ethyl o-4-Nitrophenyl Phenylphosphonothioate in Hens [R] . Abou-Donia, M. B. , Reichert, B. L. , Ashry, M. A. 1983

机译：单剂量口服o-4-硝基苯基苯基硫代磷酸酯在母鸡体内的吸收，分布，排泄和代谢

KAE609 (Cipargamin), a New Spiroindolone Agent for the Treatment of Malaria: Evaluation of the Absorption, Distribution, Metabolism, and Excretion of a Single Oral 300-mg Dose of 14CKAE609 in Healthy Male Subjects

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