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GRL-079, a Novel HIV-1 Protease Inhibitor, Is Extremely Potent against Multidrug-Resistant HIV-1 Variants and Has a High Genetic Barrier against the Emergence of Resistant Variants

机译：GRL-079新型HIV-1蛋白酶抑制剂是针对多药抗性HIV-1变体极其有效，并且对抗性变体的出现具有高遗传障碍

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Nicole S. Delino; Manabu Aoki; Hironori Hayashi; Shin-ichiro Hattori; Simon B. Chang; Yuki Takamatsu; Cuthbert D. Martyr; Debananda Das; Arun K. Ghosh; Hiroaki Mitsuya;
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1. GRL-079, a Novel HIV-1 Protease Inhibitor, Is Extremely Potent against Multidrug-Resistant HIV-1 Variants and Has a High Genetic Barrier against the Emergence of Resistant Variants [J] . Delino Nicole S., Aoki Manabu, Hayashi Hironori, Journal of neurosurgical sciences . 2018,第5期

机译：GRL-079是一种新型HIV-1蛋白酶抑制剂，对多药抗性HIV-1变体极其有效，并且具有抗抗性变体的出现的高遗传障碍
2. GRL-079, a Novel HIV-1 Protease Inhibitor, Is Extremely Potent against Multidrug-Resistant HIV-1 Variants and Has a High Genetic Barrier against the Emergence of Resistant Variants [J] . Delino Nicole S., Aoki Manabu, Hayashi Hironori, Antimicrobial agents and chemotherapy. . 2018,第5期

机译：GRL-079是一种新型HIV-1蛋白酶抑制剂，对多药抗性HIV-1变体极其有效，并且具有抗抗性变体的出现的高遗传障碍
3. Novel Protease Inhibitors Containing C-5-Modified bis-Tetrahydrofuranylurethane and Aminobenzothiazole as P2 and P2 ' Ligands That Exert Potent Antiviral Activity against Highly Multidrug-Resistant HIV-1 with a High Genetic Barrier against the Emergence of Drug Resistance [J] . Takamatsu Yuki, Aoki Manabu, Bulut Haydar, Antimicrobial agents and chemotherapy. . 2019,第8期

机译：含有C-5-改性双 - 四氢呋喃烷基氨基乙烷的新型蛋白酶抑制剂，作为P2和P2'配体，其对高度多药抗性HIV-1发挥有效的抗病毒活性，具有高遗传障碍，免受耐药性的出现
4. Novel synthetic approaches to potent HIV-1 protease inhibitors and prodrugs [C] . Wieslaw Kazmierski, Eric Furfine, Andrew Spaltenstein, European Peptide Symposium . 2002

机译：具有强效HIV-1蛋白酶抑制剂和前药的新型合成方法
5. Structure based design of potent inhibitors against multidrug-resistant HIV-1 protease variants. [D] . Yedidi, Ravikiran S. 2009

机译：基于结构的抗多药HIV-1蛋白酶变体有效抑制剂的设计。
6. GRL-079 a Novel HIV-1 Protease Inhibitor Is Extremely Potent against Multidrug-Resistant HIV-1 Variants and Has a High Genetic Barrier against the Emergence of Resistant Variants [O] . Nicole S. Delino, Manabu Aoki, Hironori Hayashi, 2018

机译：GRL-079一种新型的HIV-1蛋白酶抑制剂对多药耐药的HIV-1变体具有极强的抵抗力并且对产生抗性变体具有高度的遗传屏障
7. A novel HIV-1 protease inhibitor, GRL-044, has potent activity against various HIV-1s with an extremely high genetic barrier to the emergence of HIV-1 drug resistance [O] . Manabu Aoki, Simon B. Chang, Debananda Das, 2019

机译：新型HIV-1蛋白酶抑制剂GRL-044，对各种HIV-1S具有极高的遗传障碍，对HIV-1耐药性极高的遗传障碍具有极高的遗传障碍

GRL-079, a Novel HIV-1 Protease Inhibitor, Is Extremely Potent against Multidrug-Resistant HIV-1 Variants and Has a High Genetic Barrier against the Emergence of Resistant Variants

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