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Optical Drug Monitoring: Photoacoustic Imaging of Nanosensors to Monitor Therapeutic Lithium in Vivo

机译:光学药物监测:纳米传感器的光声成像以监测体内治疗性锂

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摘要

Personalized medicine could revolutionize how primary care physicians treat chronic disease and how researchers study fundamental biological questions. To realize this goal, we need to develop more robust, modular tools and imaging approaches for in vivo monitoring of analytes. In this report, we demonstrate that synthetic nanosensors can measure physiologic parameters with photoacoustic contrast, and we apply that platform to continuously track lithium levels in vivo. Photoacoustic imaging achieves imaging depths that are unattainable with fluorescence or multiphoton microscopy. We validated the photoacoustic results that illustrate the superior imaging depth and quality of photoacoustic imaging with optical measurements. This powerful combination of techniques will unlock the ability to measure analyte changes in deep tissue and will open up photoacoustic imaging as a diagnostic tool for continuous physiological tracking of a wide range of analytes.
机译:个性化医学可以彻底改变初级保健医生如何治疗慢性病以及研究人员如何研究基本生物学问题。为了实现这一目标,我们需要开发更强大的模块化工具和成像方法,以对被分析物进行体内监测。在本报告中,我们证明了合成的纳米传感器可以通过光声对比来测量生理参数,并且我们将该平台应用于持续追踪体内锂水平。光声成像可达到荧光或多光子显微镜无法达到的成像深度。我们验证了光声结果,该结果可通过光学测量说明光声成像的卓越成像深度和质量。这种强大的技术组合将释放测量深部组织中分析物变化的能力,并将开辟光声成像技术,作为连续生理跟踪各种分析物的诊断工具。

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