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Rational design of a live-attenuated eastern equine encephalitis virus vaccine through informed mutation of virulence determinants

机译：通过毒力决定因素的知情突变，通过知情突变实现活化的东部大当量的理性设计疫苗

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Derek W. Trobaugh; Chengqun Sun; Matthew D. Dunn; Douglas S. Reed; William B. Klimstra;
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1. Rational design of a live-attenuated eastern equine encephalitis virus vaccine through informed mutation of virulence determinants [J] . Derek W. Trobaugh, Chengqun Sun, Matthew D. Dunn, PLoS Pathogens . 2019,第2期

机译：通过毒力决定簇的已知突变合理设计减毒的东部马脑炎病毒活疫苗
2. Can understanding the virulence mechanisms of RNA viruses lead us to a vaccine against eastern equine encephalitis virus and other alphaviruses? [J] . TrobaughD.W., RymanK.D., KlimstraW.B. Expert review of vaccines . 2014,第12期

机译：了解RNA病毒的毒力机制是否可以使我们研制出针对东部马脑炎病毒和其他甲型病毒的疫苗？
3. Can understanding the virulence mechanisms of RNA viruses lead us to a vaccine against eastern equine encephalitis virus and other alphaviruses? [J] . TrobaughD.W., RymanK.D., KlimstraW.B. Expert review of vaccines . 2014,第12期

机译：能够理解RNA病毒的毒力机制，引导我们对东部马脑炎病毒和其他alphavirouses的疫苗？
4. Comparative Epidemiologies of Eastern Equine Encephalitis Virus, Western Equine Encephalitis Virus, Venezuelan Equine Encephalitis Virus, and West Nile Virus [C] . Charles H. Calisher Annual Meeting of the American Society for Veterinary Clinical Pathology . 2004

机译：东部大雄脑炎病毒，西马脑炎病毒，委内瑞拉脑脑炎病毒和西尼罗河病毒的比较流行病学
5. Development of improved dengue 2 antigen configurations for a Venezuelan equine encephalitis virus replicon particle-launched dengue vaccine [D] . Webb, Drue Laine 2008

机译：委内瑞拉马脑炎病毒复制子颗粒登革热疫苗的改进登革2抗原构型的开发
6. Rational design of a live-attenuated eastern equine encephalitis virus vaccine through informed mutation of virulence determinants [O] . Derek W. Trobaugh, Chengqun Sun, Matthew D. Dunn, 2019

机译：通过毒力决定簇的已知突变合理设计减毒的东部马脑炎病毒活疫苗
7. Structural and Nonstructural Protein Genome Regions of Eastern Equine Encephalitis Virus Are Determinants of Interferon Sensitivity and Murine Virulence▿ [O] . Aguilar, Patricia V., Adams, A. Paige, Wang, Eryu, 2008

机译：东部马脑炎病毒的结构和非结构蛋白基因组区域是干扰素敏感性和鼠毒力的决定因素▿
8. Multi-Agent Alphavirus DNA Vaccine Delivered by Intramuscular Electroporation Elicits Robust and Durable Virus Specific Immune Responses in Mice and Rabbits and Completely Protects Mice against Lethal Venezuelan, Western, and Eastern Equine Encephalitis Virus Aerosol Challenges. [R] . Dupuy, L. C., Richards, M. J., Livingston, B. D., 2016

机译：通过肌内电穿孔提供的多剂甲病毒DNa疫苗在小鼠和家兔中引发健壮和耐久的病毒特异性免疫应答，并完全保护小鼠免受致命的委内瑞拉，西方和东方马脑炎病毒气溶胶挑战。

Rational design of a live-attenuated eastern equine encephalitis virus vaccine through informed mutation of virulence determinants

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