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The Emergence of Different Resistance Mechanisms toward Nucleoside Inhibitors Is Explained by the Properties of the Wild Type HIV-1 Reverse Transcriptase

机译：通过野生型HIV-1逆转录酶的性质来解释不同抵抗机制的出现朝向核苷抑制剂

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Catherine Isel; Chantal Ehresmann; Philippe Walter; Bernard Ehresmann; Roland Marquet;
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1. Structures of Tyr188Leu mutant and wild-type HIV-1 reverse transcriptase complexed with the non-nucleoside inhibitor HBY 097: Inhibitor flexibility is a useful design feature for reducing drug resistance [J] . Hsiou Y., Ding JP., Clark AD., Journal of Molecular Biology . 1998,第2期

机译：与非核苷抑制剂HBY 097复合的Tyr188Leu突变体和野生型HIV-1逆转录酶的结构：抑制剂的柔韧性是降低耐药性的有用设计特征
2. Selective pressure of a quinoxaline nonnucleoside inhibitor of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT) on HIV-1 replication results in the emergence of nucleoside RT-inhibitor-specific (RT Leu-74 - Val or Ile and Val-7 [J] . Jorg-Peter Kleim, Manfred Rosner, Irvin Winkler Proceedings of the National Academy of Sciences of the United States of America . 1996,第1期

机译：1型人类免疫缺陷病毒（HIV-1）逆转录酶（RT）喹喔啉非核苷抑制剂对HIV-1复制的选择性压力导致出现核苷RT抑制剂特异性（RT Leu-74-Val或Ile和Val -7
3. Simple,Short Peptide Derivatives of a Sulfonylindolecarboxamide (L-737,126) Active in Vitro against HIV-1 Wild Type and Variants Carrying Non-Nucleoside Reverse Transcriptase Inhibitor Resistance Mutations [J] . Romano Silvestri, Marino Artico, Gabriella De Martino Journal of Medicinal Chemistry . 2004,第15期

机译：磺酰吲哚羧酰胺（L-737,126）的体外的简单，短肽衍生物，具有抗HIV-1野生型和携带非核苷逆转录酶抑制剂抗性突变的变体的体外活性。
4. A Novel Detection of Non-nucleoside Reverse Transcriptase Inhibitors (NNRTIs) for HIV-1 with AlGaN/GaN High Electron Mobility Transistors [C] . Yen-Wen Kang, Geng-Yen Lee, Jen-Inn Chyi, Symposium on wide bandgap semiconductor materials and devices;Meeting of the Electrochemical Society . 2013

机译：AlGaN / GaN高电子迁移率晶体管对HIV-1的非核苷逆转录酶抑制剂（NNRTIs）的新型检测
5. Do nucleoside analog-resistance mutations increase the fidelity of human immunodeficiency virus type-1 (HIV-1) reverse transcriptase? [D] . Curr, Kenneth Andrew. 2003

机译：核苷类似物抗性突变是否增加了人类1型免疫缺陷病毒（HIV-1）逆转录酶的保真度？
6. Selective pressure of a quinoxaline nonnucleoside inhibitor of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT) on HIV-1 replication results in the emergence of nucleoside RT-inhibitor-specific (RT Leu-74--Val or Ile and Val-75--Leu or Ile) HIV-1 mutants. [O] . J P Kleim, M Rösner, I Winkler, 1996

机译：喹喔啉非1型人类免疫缺陷病毒（HIV-1）逆转录酶（RT）抑制剂对HIV-1复制的选择性压力导致出现核苷RT抑制剂特异性（RT Leu-74- Val或Ile和Val-75- Leu或Ile）HIV-1突变体。
7. Distinct Mechanisms of HIV-1 Hypersusceptibility to Non-Nucleoside Reverse Transcriptase Inhibitors: A Discussion of Nucleoside Reverse Transcriptase Inhibitor Induced Mutations V118I, H208Y, and T215Y [O] . Clark Shauna Antoinette 2008

机译：HIV-1对非核苷逆转录酶抑制剂的高度敏感性的不同机制：核苷逆转录酶抑制剂诱导的突变V118I，H208Y和T215Y的讨论

The Emergence of Different Resistance Mechanisms toward Nucleoside Inhibitors Is Explained by the Properties of the Wild Type HIV-1 Reverse Transcriptase

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