Efficacy and Tolerability of Levosulipride, Domperidone and Metoclopramide in Patients with Non-Ulcer Functional Dyspepsia: A Comparative Analysis

摘要

Objective: This is a prospective, randomized study designedto demonstrate the efficacy of three study drugs (Levosulpiride,Domperidone and Metoclopramide) in Functional Dyspepsia.Subject recruitment was done from medicine outpatient departmentof the teaching hospital from June 2013 to November 2013.Materials and Methods: The data collection was performed by theShort-Form Leeds Dyspepsia Questionnaire (SF-LDQ), a questioninstrument for assessing the dyspeptic symptoms of functionaldyspepsia in patients enrolled for the study. The symptoms wereassessed at base line (Prior to initiation of therapy) and at 4 weeks,on a 5-point scale.Result: Among 120 patients 113 patients completed this study inthree groups (G-1 Levosulpiride 40 patients, G-2 Domperidone 35patients and G-3 Metoclopramide 38 patients) were followed up.Female gender dominated (75), occupation wise most of patientsbelonged to labour class (49). Highly significant improvement insymptoms scale was noticed in G-1 Levosulpiride 40 patients’group.Conclusion: Functional Gastrointestinal disorders are notserious ailments but have a key impact on quality of life. Overalldyspeptic symptom relief rates were significantly high in theLevosulpiride group (p<0.004) as compared to Domperidoneand Metoclopramide groups. A proper understanding of diseaseprocess by health care personnel and by sufferer is obligatory toenhance the quality of life and daunt the self/over the countermedication in this condition.