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Reduced current density, partially rescued by mexiletine, and depolarizing shift in activation of SCN5A W374G channels as a cause of severe form of Brugada syndrome

机译：降低电流密度，部分地通过甘氨酸振荡，并在SCN5A W374G频道激活中的去极化变化作为Brugada综合征严重形式的原因

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Tadashi Nakajima; Tommy Dharmawan; Reika Kawabata‐Iwakawa; Shuntaro Tamura; Hiroshi Hasegawa; Takashi Kobari; Masaki Ota; Shoichi Tange; Masahiko Nishiyama; Yoshiaki Kaneko; Masahiko Kurabayashi;
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1. Compound Heterozygous SCN5A Mutations in Severe Sodium Channelopathy With Brugada Syndrome: A Case Report [J] . Nijak Aleksandra, Labro Alain J., De Wilde Hans, Frontiers in Cardiovascular Medicine . 2020,第1期

机译：Brugada综合征严重钠通道病中的复合杂合子SCN5A突变：案例报告
2. SCN5A(K817E), a novel Brugada syndrome-associated mutation that alters the activation gating of Na(V)1.5 channel [J] . Kinoshita Koshi, Takahashi Hiroyuki, Hata Yukiko, Heart rhythm: the official journal of the Heart Rhythm Society . 2016,第5期

机译：SCN5A（K817E），与Brugada综合征相关的新型突变，可改变Na（V）1.5通道的激活门控
3. p.D1690N sodium voltage-gated channel subunit 5 mutation reduced sodium current density and is associated with Brugada syndrome [J] . Zeng Zhipeng, Xie Qiang, Huang Yuan, Molecular medicine reports . 2016,第6aPta2期

机译：p.D1690N钠电压门控通道亚基5突变降低钠电流密度，并与Brugada综合征相关
4. Reducing Back Channel Threshold Voltage Shifts of Partially Depleted SOI by Si Ion Implantation [C] . He Wei, Zhang En-xia, Qian Cong, IEEE International SOI Conference . 2006

机译：通过Si离子植入减少部分耗尽的SOI的后沟道阈值电压偏移
5. Reduced current density partially rescued by mexiletine and depolarizing shift in activation of SCN5A W374G channels as a cause of severe form of Brugada syndrome [O] . Tadashi Nakajima, Tommy Dharmawan, Reika Kawabata‐Iwakawa, 2021

机译：降低电流密度部分地通过甘氨酸振荡并在SCN5A W374G频道激活中的去极化变化作为Brugada综合征严重形式的原因
6. Expression defect of the rare variant/Brugada mutation R1512W depends upon the SCN5A splice variant background and can be rescued by mexiletine and the common polymorphism H558R [O] . Rou-Mu Hu, Evelyn J. Song, David J. Tester, 2021

机译：稀有变体/巴鲁金突变R1512W的表达缺陷取决于SCN5A剪接变体背景，可以通过梅西汀和常见多态性H558R拯救

Reduced current density, partially rescued by mexiletine, and depolarizing shift in activation of SCN5A W374G channels as a cause of severe form of Brugada syndrome

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