Natural killer (NK) cells are a crucial part of the innate immune system and play critical roles in host anti-viral, anti-microbial, and antitumorudresponses. The elucidation of NK cell biology and their therapeutic use are actively being pursued with 200 clinical trials currently underway. In thisudreview, we outline the role of NK cells in cancer immunotherapies and summarize current noninvasive imaging technologies used to track NK cells in vivoudto investigate mechanisms of action, develop new therapies, and evaluate efficacy of adoptive transfer.
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