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Functional analysis of non-hotspot AKT1 mutants found in human breast cancers identifies novel driver mutations: implications for personalized medicine

机译：人乳腺癌中发现的非热点Akt1突变体的功能分析鉴定了新的驾驶员突变：对个性化医学的影响

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Kyung H. Yi; Jossette Axtmayer; John P. Gustin; Anandita Rajpurohit; Josh Lauring;
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1. Functional characterization of PIK3CA as a breast cancer oncogene Review of: 1. Breast cancer-associated PIK3CA mutations are oncogenic in mammary epithelial cells 2. The oncogenic properties of mutant p110 alpha and p110 beta phosphatidylinositol 3-kinases in human mammary epithelial cells [J] . H. L. Bennett Breast cancer online: BCO . 2006,第7期

机译：PIK3CA作为乳腺癌癌基因的功能表征综述：1.与乳腺癌相关的PIK3CA突变在乳腺上皮细胞中是致癌的。2.突变型p110α和p110β磷脂酰肌醇3激酶在人乳腺上皮细胞中的致癌特性。
2. Rapid targeted mutational analysis of human tumours: a clinical platform to guide personalized cancer medicine [J] . Leif W. Ellisen, Sara Akhavanfard, Thomas J. Lynch, EMBO Molecular Medicine . 2010,第5期

机译：人类肿瘤的快速靶向突变分析：指导个性化癌症医学的临床平台
3. Review: Precision medicine and driver mutations: Computational methods, functional assays and conformational principles for interpreting cancer drivers [J] . Ruth Nussinov, Hyunbum Jang, Chung-Jung Tsai, PLoS Computational Biology . 2019,第3期

机译：综述：精密医学和驱动基因突变：解释癌症驱动基因的计算方法，功能测定和构象原理
4. A Proteome Analysis of AKT1 and Mutant AKT1(E17K) in Human Mammary Epithelial Cells by Mass Spectrometry [C] . Tony Tegeler, Rachelle A. DuQuette, Courtney Van Cott, American Society for Mass Spectrometry Conference on Mass Spectrometry and Allied Topics . 2012

机译：通过质谱法通过乳腺乳腺上皮细胞中Akt1和突变Akt1（E17K）的蛋白质组分析
5. Determining the role of p53 mutation in human breast cancer progression using recombinant mutant/wild-type p53 heterozygous human mammary epithelial cell culture models. [D] . Junk, Damian Jerome. 2008

机译：使用重组突变体/野生型p53杂合性人类乳腺上皮细胞培养模型确定p53突变在人类乳腺癌进展中的作用。
6. Functional analysis of non-hotspot AKT1 mutants found in human breast cancers identifies novel driver mutations: implications for personalized medicine [O] . Kyung H. Yi, Jossette Axtmayer, John P. Gustin, 2013

机译：在人类乳腺癌中发现的非热点AKT1突变体的功能分析可确定新的驱动程序突变：对个性化医学的意义
7. Correction: Review: Precision medicine and driver mutations: Computational methods, functional assays and conformational principles for interpreting cancer drivers [O] . Ruth Nussinov, Hyunbum Jang, Chung-Jung Tsai, 2019

机译：修正：评论：精密药物和司机突变：解释癌症司机的计算方法，功能测定和构象原则

Functional analysis of non-hotspot AKT1 mutants found in human breast cancers identifies novel driver mutations: implications for personalized medicine

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