首页> 外文OA文献 >ACTR-46. AG120, A FIRST-IN-CLASS MUTANT IDH1 INHIBITOR IN PATIENTS WITH RECURRENT OR PROGRESSIVE IDH1 MUTANT GLIOMA: RESULTS FROM THE PHASE 1 GLIOMA EXPANSION COHORTS

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ACTR-46. AG120, A FIRST-IN-CLASS MUTANT IDH1 INHIBITOR IN PATIENTS WITH RECURRENT OR PROGRESSIVE IDH1 MUTANT GLIOMA: RESULTS FROM THE PHASE 1 GLIOMA EXPANSION COHORTS

机译：ACTR-46。 AG120，一种复发性或渐进式IDH1突变胶质瘤患者的一类突变体IDH1抑制剂：1型胶质瘤扩张队列的结果

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Ingo K. Mellinghoff; Mehdi Touat; Elizabeth Maher; Macarena DeLaFuente; Timothy F. Cloughesy; Matthias Holdhoff; Gregory Cote; Howard Burris; Filip Janku; Raymond Huang; Robert Young; Benjamin Ellingson; Julia Auer; Hua Liu; Jonathan Hurov; Katherine Yen; Sam Agresta; Eyal Attar; Susan Pandya; Patrick Y. Wen;
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1. Vorasidenib (AG-881): A First-in-Class, Brain-Penetrant Dual Inhibitor of Mutant IDH1 and 2 for Treatment of Glioma [J] . Konteatis Zenon, Artin Erin, Nicolay Brandon, ACS medicinal chemistry letters . 2020,第2期

机译：vorasidenib（AG-881）：突变体IDH1和2的一类级，脑渗透双抑制剂，用于治疗胶质瘤
2. 5-Azacitidine in patients with IDH1/2-mutant recurrent glioma [J] . Federici Laetitia, Capelle Laurent, Annereau Maxime, Neuro-Oncology . 2020,第8期

机译：IDH1 / 2-突变反复性胶质瘤患者的5-氮己啶
3. Pharmacodynamics of mutant- IDH1 inhibitors in glioma patients probed by in vivo 3D MRS imaging of 2-hydroxyglutarate [J] . Ovidiu C. Andronesi, Isabel C. Arrillaga-Romany, K. Ina Ly, Nature Communications . 2018,第1期

机译：通过2-羟基戊二酸的体内3D MRS成像探测神经胶质瘤患者中突变IDH1抑制剂的药效学
4. Identification of interaction networks of mutant and wild-type IDH1 in glioma cell lines [C] . Nina Overbeck, Anja Stefanski, Vanessa Scherbaum, ASMS Conference on Mass Spectrometry and Allied Topics . 2016

机译：胶质瘤细胞系中突变体和野生型IDH1相互作用网络的鉴定
5. Predicting Isocitrate Dehydrogenase 1 (IDH1) Mutation in Patients with Gliomas using a Novel Deep Learning Network [D] . Xiao, Haonan. 2019

机译：使用小说深入学习网络预测胶质瘤患者的异偶酯脱氢酶1（IDH1）突变
6. ACTR-46. AG-120 A FIRST-IN-class MUTANT IDH1 INHIBITOR IN PATIENTS WITH RECURRENT OR PROGRESSIVE IDH1 MUTANT GLIOMA: UPDATED RESULTS FROM THE PHASE 1 NON-ENHANCING GLIOMA POPULATION [O] . Ingo K Mellinghoff, Mehdi Touat, Elizabeth Maher, 2017

机译：ACTR-46。 AG-120具有复发或进展性IDH1突变型胶质瘤的患者中的一流突变IDH1抑制剂：第1阶段非增强型胶质瘤人群的最新结果
7. ACT-14 A FIRST-IN-HUMAN STUDY OF MUTANT IDH1 INHIBITOR DS-1001B IN PATIENTS WITH RECURRENT GLIOMAS [O] . Yoshiki Arakawa, Yohei Mineharu, Toshihiko Wakabayashi, 2019

机译：ACT-14复发性胶质瘤患者突变体IDH1抑制剂DS-1001B的第一人体研究

ACTR-46. AG120, A FIRST-IN-CLASS MUTANT IDH1 INHIBITOR IN PATIENTS WITH RECURRENT OR PROGRESSIVE IDH1 MUTANT GLIOMA: RESULTS FROM THE PHASE 1 GLIOMA EXPANSION COHORTS

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