首页> 外文OA文献 >Androsterone Derivatives Substituted at Position 16: Chemical Synthesis, Inhibition of Type 3 17β-hydroxysteroid Dehydrogenase, Binding Affinity for Steroid Receptors and Proliferative/antiproliferative Activity on Shionogi (AR +) Cells

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Androsterone Derivatives Substituted at Position 16: Chemical Synthesis, Inhibition of Type 3 17β-hydroxysteroid Dehydrogenase, Binding Affinity for Steroid Receptors and Proliferative/antiproliferative Activity on Shionogi (AR +) Cells

机译：在第16位取代的雄甾酮衍生物：化学合成，抑制317β-羟类脱氢酶，对类固醇受体的结合亲和力和Shionogi（Ar +）细胞上的增殖/抗增殖活性

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Béatrice Tchédam-Ngatcha; Van Luu-The; Donald Poirier;
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年度 2002
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1. Androsterone derivatives substituted at position 16: chemical synthesis, inhibition of type 3 17beta-hydroxysteroid dehydrogenase, binding affinity for steroid receptors and proliferative/antiproliferative activity on Shionogi (AR+) cells. [J] . Tchedam Ngatcha B, Luu The V, Poirier D Journal of enzyme inhibition and medicinal chemistry. . 2002,第3期

机译：在位置16处取代的雄甾酮衍生物化学合成，对3型17β-羟基类固醇脱氢酶的抑制，对类固醇受体的结合亲和力和对Shionogi（AR +）细胞的增殖/抗增殖活性。
2. Androsterone derivatives substituted at position 16: chemical synthesis, inhibition of type 3 17beta-hydroxysteroid dehydrogenase, binding affinity for steroid receptors and proliferative/antiproliferative activity on Shionogi (AR+) cells. [J] . Tchedam Ngatcha B, Luu The V, Poirier D Journal of enzyme inhibition and medicinal chemistry. . 2002,第3期

机译：在位置16处取代的雄甾酮衍生物化学合成，对3型17β-羟基类固醇脱氢酶的抑制，对类固醇受体的结合亲和力和对Shionogi（AR +）细胞的增殖/抗增殖活性。
3. 3beta-Alkyl-androsterones as inhibitors of type 3 17beta-hydroxysteroid dehydrogenase: Inhibitory potency in intact cells, selectivity towards isoforms 1, 2, 5 and 7, binding affinity for steroid receptors, and proliferative/antiproliferative activit [J] . Ngatcha BT, Laplante Y, Labrie F, Molecular and Cellular Endocrinology . 2006,第1a2期

机译：3β-烷基-雄甾酮类作为3型17β-羟基类固醇脱氢酶的抑制剂：在完整细胞中具有抑制力，对同工型1、2、5和7的选择性，对类固醇受体的结合亲和力以及增殖/抗增殖活性
4. Part One. Synthesis of optically active tryptophan derivatives with potential activity as indoleamine 2,3-dioxygenase inhibitors: An approach via asymmetric catalytic hydrogenation. Part Two. Design, synthesis and pharmacology of selective ligands for alpha1-containing GABA(A)/benzodiazepine receptor subtypes: SAR studies of beta-carbolines at positions -3 and -6 and their corresponding bivalent ligands. Part Three. First enantiospecific total synthesis of the important biogenetic intermediates, (+)-polyneuridine and (+)-polyneuridine aldehyde, as well as 16-epi-vellosimine and macusine A. [D] . Yin, Wenyuan. 2007

机译：第一部分。具有吲哚胺2,3-二加氧酶抑制剂潜在活性的旋光色氨酸衍生物的合成：一种通过不对称催化氢化的方法。第二部分。含α1的GABA（A）/苯并二氮杂receptor受体亚型的选择性配体的设计，合成和药理作用：位于-3和-6位的β-咔啉及其相应的二价配体的SAR研究。第三部分。重要生物遗传中间体，（+）-聚神经氨酸和（+）-聚神经氨酸醛，以及16-表-维西辛和Macusine A的首次对映体全合成。
5. Dihydrotestosterone synthesis pathways from inactive androgen 5α-androstane-3β17β-diol in prostate cancer cells: Inhibition of intratumoural 3β-hydroxysteroid dehydrogenase activities by abiraterone [O] . Takashi Ando, Tsutomu Nishiyama, Itsuhiro Takizawa, -1

机译：前列腺癌细胞中非活性雄激素5α-雄甾烷-3β17β-二醇的双氢睾丸激素合成途径：阿比特龙抑制肿瘤内3β-羟类固醇脱氢酶活性
6. Androsterone 3a-Ether-3b-Substituted and Androsterone 3b-Substituted Derivatives as Inhibitors of Type 3 17b-Hydroxysteroid Dehydrogenase: Chemical Synthesis and Structure-Activity Relationship [O] . -1

机译：Androsterone 3a-乙醚-3b-取代的和雄甾酮3b取代的衍生物作为317b-羟类脱氢酶的抑制剂：化学合成和结构 - 活性关系

Androsterone Derivatives Substituted at Position 16: Chemical Synthesis, Inhibition of Type 3 17β-hydroxysteroid Dehydrogenase, Binding Affinity for Steroid Receptors and Proliferative/antiproliferative Activity on Shionogi (AR +) Cells

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