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Complex Dielectric Properties of Microcrystalline Cellulose, Anhydrous Lactose, and α-Lactose Monohydrate Powders Using a Microwave-Based Open-Reflection Resonator Sensor

机译:使用微波的敞开反射谐振器传感器的微晶纤维素,无水乳糖和α-乳糖一水合物粉末的复合介电性能

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摘要

The real (ε′) and imaginary (ε″) components of the complex permittivity of anhydrous lactose and microcrystalline cellulose (MCC) under different bulk densities, moisture contents (MCs), and times of hydration (for anhydrous lactose) were measured nondestructively using a microwave resonator sensor operating in the range of 700–800 MHz. Measurements of sensor resonant frequency and conductance allow, through calibration, determination of the complex dielectric properties ε′ (relative permittivity) and ε″ (relative dielectric loss) of the test material. Characteristic graphs of ε″ versus ε′ − 1 curve for each powder were generated as a function of bulk density and MC. Such data can be used to develop empirical models for the simultaneous in situ measurement of the bulk density and MC of the powders. Unlike MCC, anhydrous lactose is converted to its hydrate form in the presence of moisture, which causes a reduction in the amount of physisorbed and “free” water and a subsequent change in the dielectric properties. For powders such as anhydrous lactose that can form a crystal hydrate in the presence of moisture, a combination of techniques such as vibrational spectroscopy together with microwave resonator measurements are appropriate to characterize, in situ , the physical and chemical properties of the powder. © 2011 Wiley-Liss, Inc. and the American Pharmacists Association J Pharm Sci 100:2920–2934, 2011
机译:实(ε')和虚部(ε“)无水乳糖和下不同的堆密度的微晶纤维素(MCC),水分含量(MCS),和水合时间(对于无水乳糖)的复介电常数的成分进行测定无损使用微波谐振器传感器的操作在700-800兆赫的范围内。传感器的谐振频率和电导的测量允许,通过校准,复介电特性的测定ε试验材料的'(相对介电常数)和ε“(相对介电损耗)。 ε“与ε'的特性图 - 每个粉末1条曲线的堆积密度和MC的函数产生。这样的数据可以被用于开发在粉末的堆积密度和MC的原位测量同时经验模型。不像MCC,无水乳糖转化成它的水合物形式在水分的存在下,这会导致在物理吸附的量和“游离”水,并在介电特性的后续更改的降低。对于粉末如无水乳糖可以形成在水分的存在下,多种技术的组合的结晶水合物如振动光谱连同微波谐振器的测量是合适的表征,原位,粉末的物理和化学性质。 ©2011 WILEY-利斯,Inc。和美国药剂师协会的J Pharm Sci 100:2920至2934年,2011

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