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The chemotherapeutic agent CX-5461 irreversibly blocks RNA polymerase I initiation and promoter release to cause nucleolar disruption, DNA damage and cell inviability

机译：化学治疗剂CX-5461不可逆地阻断RNA聚合酶I引发和启动子释放，导致核仁破坏，DNA损伤和细胞耐用性

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Jean-Clément Mars; Michel G Tremblay; Mélissa Valere; Dany S Sibai; Marianne Sabourin-Felix; Frédéric Lessard; Tom Moss;
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年度 2020
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1. Synergistic Effects of an Irreversible DNA Polymerase Inhibitor and DNA Damaging Agents on HeLa Cells (vol 12, pg 1576, 2017) [J] . Paul Rakesh, Banerjee Samya, Greenberg Marc M. Journal of land use science . 2018,第1a3期

机译：不可逆DNA聚合酶抑制剂和DNA损伤剂对HeLa细胞的协同效应（Vol 12，PG 1576,2017）
2. Synergistic Effects of an Irreversible DNA Polymerase Inhibitor and DNA Damaging Agents on HeLa Cells [J] . Rakesh Paul, Samya Banerjee, Marc M. Greenberg ACS Chemical Biology . 2018,第3期

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4. External mechanism to prevent irreversible damage to hardware components of a cellular phone (Mobile white knight) [C] . Eram Khan, Ashish Panchal 2015 International Conference on Soft Computing Techniques and Implementations . 2015

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5. Key conformational changes of Escherichia coli RNA polymerase and promoter DNA in transcription initiation. [D] . Drennan, Amanda Christine. 2012

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6. The chemotherapeutic agent CX-5461 irreversibly blocks RNA polymerase I initiation and promoter release to cause nucleolar disruption DNA damage and cell inviability [O] . Jean-Clément Mars, Michel G Tremblay, Mélissa Valere, 2020

机译：化学治疗剂CX-5461不可逆地阻断RNA聚合酶I引发和启动子释放导致核仁破坏DNA损伤和细胞耐用性
7. Targeted Disruption of Np95 Gene Renders Murine Embryonic Stem Cells Hypersensitive to DNA Damaging Agents and DNA Replication Blocks [O] . Masahiro Muto, Yasuyoshi Kanari, Eiko Kubo, 2002

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8. Molecular Biology Basis for the Response of Poly (ADP-Ribose) Polymerase and NAD Metabolism to DNA Damage Caused by Mustard Alkylating Agents [R] . Smulson, M. E. 2004

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The chemotherapeutic agent CX-5461 irreversibly blocks RNA polymerase I initiation and promoter release to cause nucleolar disruption, DNA damage and cell inviability

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