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Trans-chromosomic mice containing a human CYP3A cluster for prediction of xenobiotic metabolism in humans

机译：含有人CYP3A簇的转染染色体小鼠，用于预测人类的异骨代谢

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Yasuhiro Kazuki; Kaoru Kobayashi; Sasitorn Aueviriyavit; Takeshi Oshima; Yoshimi Kuroiwa; Yasuko Tsukazaki; Naoto Senda; Hiroki Kawakami; Sumio Ohtsuki; Satoshi Abe; Masato Takiguchi; Hidetoshi Hoshiya; Naoyo Kajitani; Shoko Takehara; Kinya Kubo; Tetsuya Terasaki; Kan Chiba; Kazuma Tomizuka; Mitsuo Oshimura;
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1. Comparison of the hepatic metabolism of triazolam in wild-type andCyp3a-knockout mice for understanding CYP3A-mediated metabolism inCYP3A-humanised mice in vivo [J] . Minegishi Genki, Kazuki Yasuhiro, Yamasaki Yuki, Xenobiotica: the fate of foreign compounds in biological systems . 2019,第7a12期

机译：在野生型和诊断小鼠中进行三唑仑肝脏代谢的比较，以了解CYP3A介导的代谢INCYP3A-人育小鼠体内
2. Involvement of CYP3A in the metabolism of eplerenone in humans and dogs: differential metabolism by CYP3A4 and CYP3A5. [J] . Cook CS, Berry LM, Kim DH, Drug Metabolism and Disposition: The Biological Fate of Chemicals . 2002,第12期

机译：CYP3A与人和狗的依普利农代谢有关：CYP3A4和CYP3A5的代谢差异。
3. Double trans-chromosomic mice: Maintenance of two individual human chromosome fragments containing Ig heavy and k loci and expression of fully human antibodies [J] . Kazuma Tomizuka, Tokuyuki Shinoharat, Hitoshi Yoshida Proceedings of the National Academy of Sciences of the United States of America . 2000,第2期

机译：双转染色体小鼠：维持两个含有Ig重链和k基因座的人类染色体片段，并表达完整的人类抗体
4. Acoustic Cluster Therapy displays theranostic capability in enhancing the effectiveness of liposomal doxorubicin treatment of human triple negative breast cancer in mice [C] . Nigel Bush, Andrew Healey, Anant Shah, IEEE International Ultrasonics Symposium . 2019

机译：声学聚类疗法在提高小鼠中提高人类三重阴性乳腺癌的脂质体Doxorubicin治疗的有效性方面的治疗能力
5. Hemicellulose and vitamin-C reduce xenobiotic-induced human T-cell alpha5beta1 integrin-mediated adhesion to fibronectin. [D] . Lee, Sangwoo. 2008

机译：半纤维素和维生素C减少了异种生物诱导的人类T细胞alpha5beta1整合素介导的对纤连蛋白的粘附。
6. PNAS Plus: Humanized UGT2 and CYP3A transchromosomic rats for improved prediction of human drug metabolism [O] . Yasuhiro Kazuki, Kaoru Kobayashi, Masumi Hirabayashi, 2019

机译：PNAS Plus：人源化的UGT2和CYP3A转染色体大鼠可改善人类药物代谢的预测
7. Xenobiotic toxicity prediction combined with xenobiotic metabolism prediction in the human body [O] . A.V. Rudik, A.V. Dmitriev, A.A. Lagunin, 2019

机译：癫痫毒性预测结合人体癫痫素代谢预测
8. Metabolism of Endosulfan-Alpha by Human Liver Microsomes and its Utility as a Simultaneous In Vitro Probe for CYP2B6 and CYP3A4 [R] . Casabar, R. C. , Wallace, A. D. , Hodgson, E. , 2006

机译：人肝微粒体对硫丹-α的代谢及其作为CYp2B6和CYp3a4同时体外探针的应用

Trans-chromosomic mice containing a human CYP3A cluster for prediction of xenobiotic metabolism in humans

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