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POS0006 NX-5948, A SELECTIVE DEGRADER OF BTK, SIGNIFICANTLY REDUCES INFLAMMATION IN A MODEL OF AUTOIMMUNE DISEASE

机译：POS0006 NX-5948，BTK的选择性降解剂，显着降低了自身免疫疾病模型中的炎症

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D. Robbins; M. Noviski; M. Tan; C. Guiducci; T. Ingallinera; D. Karr; A. Kelly; Z. Konst; A. Tenn-Mcclellan; J. Mckinnell; L. Perez; G. Hansen; R. Rountree;
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1. Oral administration of the selective GPR120/FFA4 agonist compound A is not effective in alleviating tissue inflammation in mouse models of prototypical autoimmune diseases [J] . Melanie Wannick, Siegfried Bezdek, Nathalie Guillen, Pharmacology Research & Perspectives . 2018,第6期

机译：口服GPR120 / FFA4激动剂选择性化合物A在缓解原型自身免疫性疾病小鼠模型中不能有效缓解组织炎症
2. VX-509 (Decernotinib) Is a Potent and Selective Janus Kinase 3 Inhibitor That Attenuates Inflammation in Animal Models of Autoimmune Disease [J] . Mahajan Sudipta, Hogan James K., Shlyakhter Dina, The Journal of Pharmacology and Experimental Therapeutics: Official Publication of the American Society for Pharmacology and Experimental Therapeutics . 2015,第2期

机译：VX-509（Decernotinib）是一种有效的选择性Janus激酶3抑制剂，可减轻自身免疫性疾病动物模型中的炎症。
3. VX-509 (Decernotinib) Is a Potent and Selective Janus Kinase 3 Inhibitor That Attenuates Inflammation in Animal Models of Autoimmune Disease [J] . Mahajan Sudipta, Hogan James K., Shlyakhter Dina, The Journal of Pharmacology and Experimental Therapeutics: Official Publication of the American Society for Pharmacology and Experimental Therapeutics . 2015,第2期

机译：VX-509（Defernotinib）是一种有效和选择性的Janus激酶3抑制剂，可抑制自身免疫性疾病的动物模型中的炎症
4. NANOMEDICINES FOR THE TREATMENT OF AUTOIMMUNE INFLAMMATION: ENGINEERING DESIGN, MECHANISMS AND DISEASES [C] . Pere Santamaria Nanotechnology in medicine II: briding translational in vitro and in vivo interfaces . 2018

机译：用于治疗自发炎症的纳米技术：工程设计，机理和疾病
5. Neuroinflammation in an Alzheimer's disease animal model and the effectiveness of selective suppression of glial activation. [D] . Craft, Jeffrey Michael. 2007

机译：阿尔茨海默氏病动物模型中的神经炎症以及选择性抑制神经胶质细胞活化的有效性。
6. Oral administration of the selective GPR120/FFA4 agonist compound A is not effective in alleviating tissue inflammation in mouse models of prototypical autoimmune diseases [O] . Melanie Wannick, Siegfried Bezdek, Nathalie Guillen, 2018

机译：口服GPR120 / FFA4激动剂选择性化合物A在缓解原型自身免疫性疾病小鼠模型中不能有效缓解组织炎症
7. A Novel Small-Molecule Inhibitor of Endosomal TLRs Reduces Inflammation and Alleviates Autoimmune Disease Symptoms in Murine Models [O] . Mahesh Chandra Patra, Asma Achek, Gi-Young Kim, 2020

机译：一种新的内体TLR的小分子抑制剂可减少炎症并减轻小鼠模型中的自身免疫疾病症状

POS0006 NX-5948, A SELECTIVE DEGRADER OF BTK, SIGNIFICANTLY REDUCES INFLAMMATION IN A MODEL OF AUTOIMMUNE DISEASE

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