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Characterization of the Selective Indoleamine 2,3-Dioxygenase-1 (IDO1) Catalytic Inhibitor EOS200271/PF-06840003 Supports IDO1 as a Critical Resistance Mechanism to PD-(L)1 Blockade Therapy

机译：选择性吲哚胺的表征2,3-二氧基酶-1（IDO1）催化抑制剂EOS200271 / PF-06840003支持IDO1作为PD-（L）1阻断治疗的临界电阻机制

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Bruno Gomes; Gregory Driessens; Derek Bartlett; Danying Cai; Sandra Cauwenberghs; Stefano Crosignani; Deepak Dalvie; Sofie Denies; Christopher P. Dillon; Valeria R. Fantin; Jie Guo; Marie-Claire Letellier; Wenlin Li; Karen Maegley; Reece Marillier; Nichol Miller; Romain Pirson; Virginie Rabolli; Chad Ray; Nicole Streiner; Vince R. Torti; Konstantinos Tsaparikos; Benoit J. Van den Eynde; Martin Wythes; Li-Chin Yao; Xianxian Zheng; Joseph Tumang; Manfred Kraus;
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1. 阴茎鳞状细胞癌患者吲哚胺2,3-双加氧化酶1(IDO1)表达和催化活性的上调与免疫抑制和预后不良相关 [J] . 周强华, 秦自科, 刘卓炜, 癌症（英文版） . 2020,第004期
2. Characterization of the Selective lndoleamine 2,3-Dioxygenase-1 (IDO1) Catalytic Inhibitor EOS200271/PF-06840003 Supports IDO1 as a Critical Resistance Mechanism to PD-(L)1 Blockade Therapy [J] . Gomes Bruno, Driessens Gregory, Bartlett Derek, Molecular cancer therapeutics . 2018,第12期

机译：选择性LNDOLEAMIN的表征2,3-二氧合酶-1（IDO1）催化抑制剂EOS200271 / PF-06840003支持IDO1作为PD-（L）1阻断治疗的临界电阻机制
3. IDENTIFICATION OF SECOND-GENERATION POTENT AND SELECTIVE INHIBITORS OF INDOLEAMINE-2,3-DIOXYGENASE-1 (IDO1) FOR THE TREATMENT OF CANCER [J] . Juan Jaen C., Pia Bjorck, Jordan Fridman S., European journal of cancer: official journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR) . 2015,第S1期

机译：吲哚胺-2,3-二氧合酶-1（IDO1）的第二代治疗潜力和选择性抑制剂的鉴定
4. Purification and kinetic characterization of human indoleamine 2,3-dioxygenases 1 and 2 (IDO1 and IDO2) and discovery of selective IDO1 inhibitors. [J] . Meininger D, Zalameda L, Liu Y, Biochimica et biophysica acta: BBA: International journal of biochemistry, biophysics and molecular biololgy. Proteins and Proteomics . 2011,第12期

机译：人吲哚胺2，3-二加氧酶1和2（IDO1和IDO2）的纯化和动力学表征以及选择性IDO1抑制剂的发现。
5. INCB24360 (Epacadostat) a Highly Potent and Selective Indoleamine-23-dioxygenase1 (IDO1) Inhibitor for Immuno-oncology [O] . Eddy W. Yue, Richard Sparks, Padmaja Polam, 2017

机译：INCB24360（依帕卡司他）一种高效且选择性的吲哚胺-23-双加氧酶1（IDO1）免疫肿瘤抑制剂
6. Discovery of a Novel and Selective Indoleamine 2,3-Dioxygenase (IDO-1) Inhibitor 3-(5-Fluoro-1H-indol-3-yl)pyrrolidine-2,5-dione (EOS200271/PF-06840003) and Its Characterization as a Potential Clinical Candidate [O] . Stefano Crosignani, Patrick Bingham, Pauline Bottemanne, 2017

机译：发现一种新颖和选择性吲哚胺2,3-二氧化根蛋白酶（IDO-1）抑制剂3-（5-氟-1H-吲哚-3-基）吡咯烷-2,5-二酮（EOS200271 / PF-06840003）及其表征作为潜在的临床候选人

Characterization of the Selective Indoleamine 2,3-Dioxygenase-1 (IDO1) Catalytic Inhibitor EOS200271/PF-06840003 Supports IDO1 as a Critical Resistance Mechanism to PD-(L)1 Blockade Therapy

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