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Modeling of the dissolution kinetics of arbutus wild berries-based tablets as evaluated by electric conductivity

机译:通过电导率评估的基于杨梅野生浆果的片剂的溶解动力学模型

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摘要

Lyophilized powder (LP) from Algerian arbutus wild berries (Arbutus unedo L.) was obtained. This present paper reports about the dissolution (releasing) properties of LP-based tablets, evaluated through the electric conductivity (EC) of distilled water which is employed as surrounding medium, at three different temperatures (291, 298 and 309 K). In addition to this, secondary physicochemical characteristics such as elementary analysis, color and compressibility were evaluated. Regarding the modeling of ionic transfer, among the three tested models, namely Peleg, Singh et al. and Singh and Kulshestha, the latter seems to be the most appropriate (R2 = 0.99), particularly in the case of compacted tablets under 2000 Pa. The temperature dependence of the dissolution process was also studied applying Arrhenius equation (R2>0.8) which allowed to deduce the activation energy, ranging from 18.7 to 21.4 kJ.mol-1 according to the model and compression force employed.
机译:从阿尔及利亚杨梅野生浆果(Arbutus unedo L.)获得冻干粉(LP)。本文通过在三种不同温度(291、298和309 K)下通过用作周围介质的蒸馏水的电导率(EC)评估了LP基片剂的溶解(释放)特性。除此之外,还评估了次级理化特性,例如元素分析,颜色和可压缩性。关于离子转移的建模,在三个测试模型中,即Peleg,Singh等。以及Singh和Kulshestha,后者似乎是最合适的(R2 = 0.99),尤其是在2000 Pa以下的压实片剂的情况下。还使用Arrhenius方程(R2> 0.8)研究了溶出过程的温度依赖性,该方程允许根据所使用的模型和压缩力推导活化能,范围从18.7到21.4 kJ.mol-1。

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