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Piezoelectric micropump with nanoliter per minute flow for drug delivery systems

机译:每分钟流量纳升的压电微型泵,用于药物输送系统

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摘要

Piezoelectric Actuated Valveless Micropump (PAVM) has been designed and successfully fabricated using MEMS fabrication processes. The micropump uses a PZT: Pb(ZrTi)Ox ceramic plate to actuate a silicon membrane which bends when a voltage is applied to the piezoelectric actuator. The resultant reciprocating movement of the pump membrane is then converted into pumping effect. By integrating dynamic passive valves into the device, the pump would then operate continuously with volumetric pumping rate determined by the frequency of the driving voltage. Simulation work to determine the micropump fluidic characteristics was performed using CoventorWare MemFSI™ module. The pump was fabricated on a double side polished silicon wafer via simple two-mask micromachining process. The fabricated micropump, having an outer dimension of 14 mm × 14 mm × 2 mm, was then tested with DI (deionized) water as the test liquid. A driving voltage of 16 Vpp was applied to the PZT actuator. Pump rate of 4.98 nL per min was obtained at 0.673 kHz. The fabricated micropump envisages a promising pumping method to be implemented into drug delivery systems.
机译:压电驱动无阀微型泵(PAVM)已通过MEMS制造工艺设计并成功制造。微型泵使用PZT:Pb(ZrTi)Ox陶瓷板来致动硅膜,该硅膜在向压电致动器施加电压时会弯曲。泵膜的最终往复运动随后转化为泵吸作用。通过将动态无源阀集成到设备中,泵将以由驱动电压的频率确定的容积抽速连续运行。使用CoventorWare MemFSI™模块进行了确定微泵流体特性的仿真工作。该泵是通过简单的两掩模微加工工艺在双面抛光的硅晶片上制成的。然后,用去离子水(DI)作为测试液对外部尺寸为14 mm×14 mm×2 mm的微型泵进行测试。向PZT执行器施加了16 Vpp的驱动电压。在0.673 kHz处获得每分钟4.98 nL的泵速。所制造的微型泵设想了一种有前途的泵送方法,可用于药物输送系统。

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