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Small molecules for modulating protein driven liquid-liquid phase separation in treating neurodegenerative disease

机译：用于调节蛋白质驱动液 - 液相分离的小分子在治疗神经变性疾病中

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Richard J. Wheeler; Hyun O. Lee; Ina Poser; Arun Pal; Thom Doeleman; Satoshi Kishigami; Sukhleen Kour; Eric Nathaniel Anderson; Lara Marrone; Anastasia C. Murthy; Marcus Jahnel; Xiaojie Zhang; Edgar Boczek; Anatol Fritsch; Nicolas L. Fawzi; Jared Sterneckert; Udai Pandey; Della C. David; Benjamin G. Davis; Andrew J. Baldwin; Andreas Hermann; Marc Bickle; Simon Alberti; Anthony A. Hyman;
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1. Liquid-Liquid Phase Separation Is Driven by Large-Scale Conformational Unwinding and Fluctuations of Intrinsically Disordered Protein Molecules [J] . Majumdar Anupa, Dogra Priyanka, Maity Shiny, Journal of physical chemistry letters . 2019,第14期

机译：液 - 液相分离是由大规模构象展开的驱动和本质上无序蛋白质分子的波动驱动
2. Small molecules as potent biphasic modulators of protein liquid-liquid phase separation [J] . W. Michael Babinchak, Benjamin K. Dumm, Sarah Venus, Nature Communications . 2020,第1期

机译：小分子作为蛋白质液相分离的有效双相调节剂
3. New insights of poly(ADP-ribosylation) in neurodegenerative diseases: A focus on protein phase separation and pathologic aggregation [J] . Liu, C.a, bEmail Author, Biochemical Pharmacology . 2019,第期

机译：神经变性疾病中聚（ADP-核糖基化）的新见解：重点是蛋白质相分离和病理学聚集
4. Nucleic Acids Chemistry beyond the Watson-Crick Double Helix (50):Phase separation of RNA/peptides in neurodegenerative diseases is promoted by chemical environment changes in cells [C] . Hisae Tateishi-Karimata, Ye Teng, Naoki Sugimoto 日本化学会春季年会講演予稿集 . 2018

机译：核酸化学超出Watson-Crick双螺旋（50）：通过细胞的化学环境促进了神经变性疾病中RNA /肽中的RNA /肽的相分离
5. Identification and Biophysical Characterization of Small Molecules Modulating Protein Disulfide Isomerase in Neurodegenerative Diseases [D] . Kaplan, Anna 2015

机译：小分子调节蛋白二硫键异构酶在神经退行性疾病中的鉴定和生物物理特征
6. Process optimization and protein engineering mitigated manufacturing challenges of a monoclonal antibody with liquid-liquid phase separation issue by disrupting inter-molecule electrostatic interactions [O] . Qun Du, Melissa Damschroder, Timothy M. Pabst, 2019

机译：通过破坏分子间的静电相互作用工艺优化和蛋白质工程缓解了具有液-液相分离问题的单克隆抗体的生产挑战
7. Small molecules as potent biphasic modulators of protein liquid-liquid phase separation [O] . W. Michael Babinchak, Benjamin K. Dumm, Sarah Venus, 2020

机译：小分子作为蛋白质液相分离的有效双相调节剂

Small molecules for modulating protein driven liquid-liquid phase separation in treating neurodegenerative disease

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