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Targeting Acyl Homoserine Lactone (AHL) of Pseudomonas aeruginosa Responsible for Biofilm Formation using Plant Metabolites

机译:靶向使用植物代谢物负责生物膜形成的假单胞菌铜绿假单胞菌的酰基HomoSerine内酯(AHL)

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摘要

AHL (acyl homoserine lactone) is a signaling molecule responsible for communication in gram negative bacteria, which is liable for bacterial virulence as well as biofilm formation. This study aims in targeting the AHL formation and AHL mediated virulence factor using plant extracts / plant metabolites. AHL plays a major role in pigment production, motility and rhamnolipid production in Pseudomonas aeruginosa. Inhibition of these mechanism by any mean implies that it is having impact in biofilm formation too. Plant derived metabolites/ extracts were subjected for swarming motility assay, the metabolite which inhibited the swarming motility was subjected for further study, where P. aeruginosa SU-3 was allowed to grow in the presence of the metabolite and its impact over the AHL production, pigment production and rhamnolipid production was evaluated. Curcumin was found to be effective against all the metabolites used. Thus curcumin subjected for molecular docking against ENR (enoyl carrier protein reductase), the enzyme involves in fatty acid synthesis and production of AHL.
机译:AHL(酰基HomoSerine内酯)是负责在革兰氏阴性细菌中通信的信号分子,这对于细菌毒力以及生物膜形成致敏感。本研究旨在使用植物提取物/植物代谢物靶向AHL形成和AHL介导的毒力因子。 AHL在Pseudomonas铜绿假单胞菌的颜料生产,运动和鼠霉素生产中发挥着重要作用。通过任何平均值抑制这些机制意味着它也具有对生物膜形成的影响。植物衍生的代谢物/提取物进行蜂拥而至的动力测定,进行抑制蜂拥而受动力的代谢物进行进一步的研究,其中P.铜绿假单胞菌SU-3在代谢物存在下生长及其对AHL生产的影响,评估颜料生产和rhamnolipid生产。发现姜黄素对所用的所有代谢物有效。因此,对ENR(Enoyl载体蛋白还原酶)进行分子对接的姜黄素,酶涉及脂肪酸合成和AHL的产生。

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