首页> 外文OA文献 >High-Affinity Agonist Binding Correlates with Efficacy (Intrinsic Activity) at the Human Serotonin 5-HT2A and 5-HT2C Receptors: Evidence Favoring the Ternary Complex and Two-State Models of Agonist Action

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High-Affinity Agonist Binding Correlates with Efficacy (Intrinsic Activity) at the Human Serotonin 5-HT2A and 5-HT2C Receptors: Evidence Favoring the Ternary Complex and Two-State Models of Agonist Action

机译：高亲和力激动剂结合与人血清素5-HT2A和5-HT2C受体的疗效（内在活性）相关：有利于三元复合体和两国激动作用模型的证据

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Lawrence W. Fitzgerald; Deborah S. Conklin; Carol M. Krause; Anne P. Marshall; John P. Patterson; David P. Tran; Geeta Iyer; Walter A. Kostich; Brian L. Largent; Paul R. Hartig;
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1. High-affinity agonist binding is not sufficient for agonist efficacy at 5-hydroxytryptamine2A receptors: evidence in favor of a modified ternary complex model. [J] . Roth BL, Choudhary MS, Khan N, The Journal of Pharmacology and Experimental Therapeutics: Official Publication of the American Society for Pharmacology and Experimental Therapeutics . 1997,第2期

机译：高亲和力的激动剂结合不足以对5-羟色胺2A受体产生激动剂功效：支持改良的三元复合物模型的证据。
2. (1R, 3S)-(-)-trans-PAT: a novel full-efficacy serotonin 5-HT2C receptor agonist with 5-HT2A and 5-HT2B receptor inverse agonist/antagonist activity. [J] . Booth RG, Fang L, Huang Y European Journal of Pharmacology: An International Journal . 2009,第1a3期

机译：（1R，3S）-（-）-trans-PAT：一种具有5-HT2A和5-HT2B受体反向激动剂/拮抗剂活性的新型全效5-羟色胺5-HT2C受体激动剂。
3. (1R, 3S)-(-)-trans-PAT: a novel full-efficacy serotonin 5-HT2C receptor agonist with 5-HT2A and 5-HT2B receptor inverse agonist/antagonist activity. [J] . Booth RG, Fang L, Huang Y European Journal of Pharmacology: An International Journal . 2009,第1a3期

机译：（1R，3S）-（-）-trans-PAT：一种具有5-HT2A和5-HT2B受体反向激动剂/拮抗剂活性的新型全效5-羟色胺5-HT2C受体激动剂。
4. Coupled plasmon aveguide resonance studies of agonist/antagonist binding to the human delta-opioid receptor provide new structural insights into the three-state model for receptor-ligand interactions [C] . Z.Salamon, I.Alves, S.Cowell, the International Peptide Symposium . 2001

机译：偶联的等离子体Aveguide对人δ-阿片受体的激动剂/拮抗剂结合的共振研究为受体 - 配体相互作用的三种模型提供了新的结构性见解
5. (1R 3S)-(−)-Trans-PAT: A novel full-efficacy serotonin 5-HT2C receptor agonist with 5-HT2A and 5-HT2B receptor inverse agonist/antagonist activity [O] . Raymond G. Booth, Lijuan Fang, Yingsu Huang, -1

机译：（1R3S） - （ - ） - 跨帕特：一种新型全疗效血清素5-HT2C受体激动剂具有5-HT2A和5-HT2B受体反向激动剂/拮抗剂活性
6. (1R, 3S)-(−)-Trans-PAT: A novel full-efficacy serotonin 5-HT2C receptor agonist with 5-HT2A and 5-HT2B receptor inverse agonist/antagonist activity [O] . Department of Medicinal Chemistry, College of Pharmacy, University of Florida, Gainesville, FL 32610-0485, United States ( host institution ), Booth, Raymond G. ( UF author ), Fang, Lijuan ( UF author ), 2009

机译：（1R，3S）-（-）-Trans-PAT：一种新型的5-羟色胺5-HT2C受体激动剂，具有5-HT2A和5-HT2B受体反向激动剂/拮抗剂活性
7. Spare Receptors, Partial Agonists, and Ternary Complex Model of Drug Action [R] . Homer, L. D., Nielsen, T. B. 1987

机译：备用受体，部分激动剂和药物作用的三元复合模型

High-Affinity Agonist Binding Correlates with Efficacy (Intrinsic Activity) at the Human Serotonin 5-HT2A and 5-HT2C Receptors: Evidence Favoring the Ternary Complex and Two-State Models of Agonist Action

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