Some compounds, characterized by phenylethenyl moiety, such as methyl cinnamate and caffeic acid phenethyl ester, are able to inhibit C. albicans biofilm formation. On these bases, and as a consequence of our previous work, we synthesized a series of cinnamoyl ester and amide derivatives in order to evaluate them for the activity against C. albicans biofilm and planktonically grown cells. The most active compounds 7 and 8 showed ⩾50% biofilm inhibition concentrations (BMIC50) of 2 μg/mL and 4 μg/mL respectively, against C. albicans biofilm formation; otherwise, 7 showed an interesting activity also against mature biofilm, with BMIC50 of 8 μg/mL
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机译：一些化合物，其特征在于苯基乙烯部分，例如肉桂酸甲酯和咖啡酸苯乙烷酯，能够抑制C. albicans Biofilm的形成。在这些基础上，由于我们以前的工作，我们合成了一系列肉桂酰酯和酰胺衍生物，以评估它们对C. albicans生物膜和氏氏菌植物生长细胞的活性。最活跃的化合物7和8分别显示出2μg/ ml和4μg/ ml的±50％生物膜抑制浓度（BMIC50），反对C. albicans Biofilm形成;否则，7显示出对成熟生物膜的有趣活动，BMIC50为8μg/ ml
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