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Preparation and Properties of Carboxymethyl Chitosan/Alginate/Tranexamic Acid Composite Films

机译:羧甲基壳聚糖/藻酸盐/宁酸复合膜的制备及性能

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摘要

In this study, the porous composite films of carboxymethyl chitosan/alginate/tranexamic acid were fabricated, with calcium chloride as the crosslinking agent and glycerin as a plasticizer. The composite films were characterized by scanning electron microscopy (SEM) and Fourier transform infrared (FTIR) spectroscopy. The properties of the composite films, including water absorption, air permeability, and cumulative release rate, were tested. In addition, their hemostatic performance was evaluated. The results showed that the appearance of the films with good adhesion was smooth and porous. FTIR showed that chemical crosslinking between carboxymethyl chitosan and sodium alginate was successful. The excellent cumulative release of tranexamic acid in the composite films (60–80%) gives the films a significant procoagulant effect. This has good prospects for the development of medical hemostasis materials.
机译:在该研究中,制造羧甲基壳聚糖/藻酸盐/藻酸盐/藻酸盐/藻酸盐/宁酸的多孔复合薄膜,用氯化钙作为交联剂和甘油作为增塑剂。通过扫描电子显微镜(SEM)和傅里叶变换红外(FTIR)光谱,表征复合膜。测试复合薄膜的性质,包括吸水,透气性和累积释放率。此外,评估其止血性能。结果表明,具有良好粘合性的薄膜的外观光滑且多孔。 FTIR显示羧甲基壳聚糖和海藻酸钠之间的化学交联成功。复合薄膜中宁酸的优异累积释放(60-80%)使薄膜具有显着的促凝血效果。这对医学止血材料的发展具有良好的前景。

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