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First-in-Human Randomized Study to Assess the Safety and Immunogenicity of an Investigational Respiratory Syncytial Virus (RSV) Vaccine Based on Chimpanzee-Adenovirus-155 Viral Vector–Expressing RSV Fusion, Nucleocapsid, and Antitermination Viral Proteins in Healthy Adults

机译：首先是人类随机的研究，评估基于黑猩猩 - 腺病毒-155病毒载体的RSV融合，核衣壳和健康成人的硝基氨基葡萄病毒蛋白的安全性和免疫原性的疫苗的安全性和免疫原性

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Paola Cicconi; Claire Jones; Esha Sarkar; Laura Silva-Reyes; Paul Klenerman; Catherine de Lara; Claire Hutchings; Philippe Moris; Michel Janssens; Laurence A Fissette; Marta Picciolato; Amanda Leach; Antonio Gonzalez-Lopez; Ilse Dieussaert; Matthew D Snape;
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1. Immunogenicity and safety of a respiratory syncytial virus fusion protein (RSV F) nanoparticle vaccine in older adults [J] . Louis Fries, Vivek Shinde, Jeffrey J. Stoddard, Immunity Ageing . 2017,第1期

机译：老年人呼吸道合胞病毒融合蛋白（RSV F）纳米颗粒疫苗的免疫原性和安全性
2. Safety and immunogenicity of a respiratory syncytial virus fusion glycoprotein F subunit vaccine in healthy adults: Results of a phase 1, randomized, observer-blind, controlled, dosage-escalation study [J] . Vaccine . 2019,第20期

机译：健康成人呼吸道合胞病毒融合糖蛋白F亚单蛋白的安全性和免疫原性：1期，随机，观察者盲，控制，剂量升级研究的结果
3. Recombinant low-seroprevalent adenoviral vectors Ad26 and Ad35 expressing the respiratory syncytial virus (RSV) fusion protein induce protective immunity against RSV infection in cotton rats [J] . Widjojoatmodjo Myra N., Bogaert Lies, Meek Bob, Vaccine . 2015,第41期

机译：表达呼吸道合胞病毒（RSV）融合蛋白的重组低血清流行腺病毒载体Ad26和Ad35诱导抗棉花RSV感染的保护性免疫
4. DNA Vaccines Co-expressing Containing Hsp70 and GP5/M Protein of Porcine Reproductive and Respiratory Syndrome Virus (PRRSV) Display Enhanced Immunogenicity [C] . Zuo Lan, Yan Qi-Gui, Lei Yan, International Conference on Mechanical Engineering and Intelligent Systems . 2012

机译：DNA疫苗共同含有HSP70和猪生殖和呼吸综合征病毒（PRRSV）的GP5 / M蛋白显示出增强的免疫原性
5. A rhesus monkey model of respiratory syncytial virus (RSV) to evaluate the immunogenicity and protective efficacy of a DNA vaccine. [D] . Vaughan, Kerrie Colleen McArthur. 2002

机译：呼吸道合胞病毒（RSV）的恒河猴模型，用于评估DNA疫苗的免疫原性和保护功效。
6. Safety and immunogenicity of novel respiratory syncytial virus (RSV) vaccines based on the RSV viral proteins F N and M2-1 encoded by simian adenovirus (PanAd3-RSV) and MVA (MVA-RSV); protocol for an open-label dose-escalation single-centre phase 1 clinical trial in healthy adults [O] . C A Green, E Scarselli, M Voysey, 2015

机译：基于猿猴腺病毒（PanAd3-RSV）和MVA（MVA-RSV）编码的RSV病毒蛋白FN和M2-1的新型呼吸道合胞病毒（RSV）疫苗的安全性和免疫原性；健康成人的开放标签剂量递增单中心1期临床试验方案
7. A Phase I Randomized, Observer-Blind, Controlled, Dose Escalation Trial of the Safety and Tolerability of Two Intramuscular Doses of DPX-RSV(A), a Respiratory Syncytial Virus (RSV) Vaccine Containing RSV SH Antigen and a Novel Adjuvant DepoVax, or SH Antigen Co-administered With Aluminum Hydroxide, or Placebo to Healthy Adults ≥50–64 Years of Age [O] . Joanne Langley, Lisa Macdonald, Genevieve Weir, 2016

机译：一期随机化，观察者盲，受控，剂量升级的安全性和含有RSV SH抗原的呼吸道合胞病毒（RSV）疫苗的安全性和耐受性，含有RSV SH抗原和新型佐剂Depovax，或SH抗原与氢氧化铝，或安慰剂至健康成人≥50-64岁

First-in-Human Randomized Study to Assess the Safety and Immunogenicity of an Investigational Respiratory Syncytial Virus (RSV) Vaccine Based on Chimpanzee-Adenovirus-155 Viral Vector–Expressing RSV Fusion, Nucleocapsid, and Antitermination Viral Proteins in Healthy Adults

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