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Substitutions at Position 105 in SHV Family β-Lactamases Decrease Catalytic Efficiency and Cause Inhibitor Resistance

机译：SHV家族β-内酰胺酶在SHV系列105的取代降低催化效率并引起抑制剂抗性

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Mei Li; Benjamin C. Conklin; Magdalena A. Taracila; Rebecca A. Hutton; Marion J. Skalweit;
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1. Substitutions at position 105 in SHV family β-lactamases decrease catalytic efficiency and cause inhibitor resistance [J] . LiM., ConklinB.C., TaracilaM.A., Antimicrobial agents and chemotherapy. . 2012,第11期

机译：SHV家族β-内酰胺酶105位的取代基降低催化效率并引起抑制剂抗性
2. Substitution of Arg-244 by Cys or Ser in SHV-1 and SHV-5 beta-lactamases confers resistance to mechanism-based inhibitors and reduces catalytic efficiency of the enzymes [J] . Giakkoupi P., Legakis NJ., Tzouvelekis LS., FEMS Microbiology Letters . 1998,第1期

机译：在SHV-1和SHV-5β-内酰胺酶中被Cys或Ser取代Arg-244赋予对基于机理的抑制剂的抗性并降低了酶的催化效率
3. Overcoming resistance to beta-lactamase inhibitors: Comparing sulbactam to novel inhibitors against clavulanate resistant SHV enzymes with substitutions at ambler position 244 [J] . Thomson JM, Distler AM, Bonomo RA Biochemistry . 2007,第40期

机译：克服对β-内酰胺酶抑制剂的耐药性：将舒巴坦与抗克拉维酸抗SHV酶的新型抑制剂进行比较，并在漫步者244位进行取代
4. Amino acid substitutions in ACCase gene of barley grass {Hordeum glaucum Steud.) associated with resistance to ACCase-inhibiting herbicides [C] . Lovrcet Singh Shergill, Christopher Preston, Peter Boutsalis, Australasian Weeds Conference . 2016

机译：大麦草（Hordeum glaucum Steud）Accase基因中的氨基酸取代。抗抑制抑制除草剂的抗性相关
5. Structure Based Inhibitor Discovery Targeting Multiple β-Lactamases Involved in Antibiotic Resistance [D] . Akhtar, Afroza. 2020

机译：基于结构的抑制剂发现靶向抗生素抗性的多个β-内酰胺酶
6. Substitutions at Position 105 in SHV Family β-Lactamases Decrease Catalytic Efficiency and Cause Inhibitor Resistance [O] . Mei Li, Benjamin C. Conklin, Magdalena A. Taracila, 2012

机译：SHV家族β-内酰胺酶105位的取代基降低催化效率并引起抗药性
7. Substitution of Arg-244 by Cys or Ser in SHV-1 and SHV-5 Î²-lactamases confers resistance to mechanism-based inhibitors and reduces catalytic efficiency of the enzymes [O] . Panagiota Giakkoupi, Eva Tzelepi, Nicholas J Legakis, 1998

机译：Cys或SER在SHV-1和SHV-5β-内酰胺酶中取代ARG-244赋予对机理抑制剂的抗性，降低酶的催化效率

Substitutions at Position 105 in SHV Family β-Lactamases Decrease Catalytic Efficiency and Cause Inhibitor Resistance

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