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Structure-based Discovery of Novel Small Molecule Wnt Signaling Inhibitors by Targeting the Cysteine-rich Domain of Frizzled

机译：基于结构的新型小分子Wnt信号抑制剂的发现，靶向富含半胱氨酸的毛囊域

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Ho-Jin Lee; Ju Bao; Ami Miller; Chi Zhang; Jibo Wu; Yiressy C. Baday; Cristina Guibao; Lin Li; Dianqing Wu; Jie J. Zheng;
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1. Structure-based prediction of Wnt binding affinities for Frizzled-type cysteine-rich domains [J] . Mark Agostino, Sebastian ?ther-Gee Pohl, Arun Dharmarajan The Journal of biological chemistry . 2017,第27期

机译：基于结构的Wnt结合亲和力的卷曲型半胱氨酸域的结构预测
2. The cysteine-rich frizzled domain of Frzb-1 is required and sufficient for modulation of Wnt signaling [J] . Keming Lin, Shouwen Wang, Martin A. Julius Proceedings of the National Academy of Sciences of the United States of America . 1997,第21期

机译：Frzb-1的富含半胱氨酸的卷曲结构域是必需的，并且足以调节Wnt信号
3. Wnt5a promotes Frizzled-4 signalosome assembly by stabilizing cysteine-rich domain dimerization [J] . DeBruine Zachary J., Ke Jiyuan, Harikumar Kaleeckal G., Genes and Development: a Journal Devoted to the Molecular Analysis of Gene Expression in Eukaryotes, Prokaryotes, and Viruses . 2017,第9期

机译：通过稳定富含半胱氨酸的结构域二聚化，促进WNT5A促进Frizzled-4信号组件
4. Nanoparticles Coated with Frizzled7 Antibodies Enable Multivalent Binding for Enhanced Wnt Signaling Inhibition in Triple-Negative Breast Cancer [C] . Rachel S. Riley, Emily S. Day Society for Biomaterials annual meeting and exposition . 2018

机译：纳米颗粒涂有Frizzled7抗体使三价乳腺癌中增强Wnt信号抑制的多价结合。
5. Inhibition of TLR2 Signaling by Small Molecule Inhibitors Targeting a Pocket Within the TLR2 TIR Domain. [D] . Mistry, Pragnesh Dilipkumar. 2015

机译：针对小分子抑制剂的TLR2 TIR域内的小分子对TLR2信号的抑制。
6. Structure-based Discovery of Novel Small Molecule Wnt Signaling Inhibitors by Targeting the Cysteine-rich Domain of Frizzled [O] . Ho-Jin Lee, Ju Bao, Ami Miller, 2015

机译：通过结构化发现新型的小分子Wnt信号抑制剂通过靶向富半胱氨酸的卷曲蛋白域
7. Amyloid-beta binds to the extracellular cysteine-rich domain of frizzled and inhibits wnt/beta-catenin signaling [O] . Magdesian, Margaret H., Carvalho, Milena M. V. F., Mendes, Fabio A., 2008

机译：淀粉样蛋白β结合到卷曲的胞外富含半胱氨酸的结构域，并抑制wnt /β-catenin信号传导
8. Structure-Based Approach for Discovery of Small Molecule Inhibitors Targeted at Bcl-2 [R] . Wang, S. 2006

机译：基于结构的发现针对Bcl-2的小分子抑制剂的方法

Structure-based Discovery of Novel Small Molecule Wnt Signaling Inhibitors by Targeting the Cysteine-rich Domain of Frizzled

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