Potent CRISPR-Cas9 inhibitors fromStaphylococcusgenomes

机译：有效的CRISPR-CAS9抑制剂来自透明岩圆锥因

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Kyle E. Watters; Haridha Shivram; Christof Fellmann; Rachel J. Lew; Blake McMahon; Jennifer A. Doudna;
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机译：窥镜抑制剂：合成有效的柚皮苷酶抑制剂L-DIM [1,4-dideoxy-1,4-imino-L-甘露醇]，DIM的对映异构体[1,4-dideoxy-1,4-imino-D-甘露醇]一种有效的α-D-甘露糖苷酶抑制剂
2. Discovery of a Novel Class of Potent Coumarin Monoamine Oxidase B Inhibitors: Development and Biopharmacological Profiling of 7-[(3-Chlorobenzyl)oxy]-4-[(methylamino)methyl]-2H-chromen-2-one Methanesulfonate (NW-1772) as a Highly Potent, Selective, Reversible, and Orally Active Monoamine Oxidase B Inhibitor [J] . Pisani L, Muncipinto G, Miscioscia TF, Journal of Medicinal Chemistry . 2009,第21期

机译：一类新型强力香豆素单胺氧化酶B抑制剂的发现：7-[（3-氯苄基）氧基] -4-[（甲基氨基）甲基] -2H-铬-2-酮甲烷磺酸盐（NW-1772）的开发和生物药理学分析）作为高效，选择性，可逆和口服活性单胺氧化酶B抑制剂
3. 1230 Cediranib (an oral, highly potent VEGF signalling inhibitor) in combination with saracatinib (AZD0530; a potent, selective Src inhibitor): a phase I open-label study in patients with advanced solid tumours [J] . T.Trarbach, J.Drevs, D.Strumberg, European Journal of Cancer Supplements . 2009,第2期

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4. Development and characterization of potent peptide inhibitors of p60~(C-Src) PTK using pseudosubstrate-based inhibitor design approach [C] . Jayesh R.Kamath, Ruiwu Liu, Amanda M.Enstrom, the International Peptide Symposium . 2001

机译：基于假素抑制剂设计方法的P60〜（C-SRC）PTK有效肽抑制剂的开发与表征
5. P27 as a molecular target for cancer therapeutics: Discovering small molecule inhibitors of p27 proteolysis and structure-activity relationship and mechanistic studies of largazole, a potent inhibitor of histone deacetylase . [D] . Ungermannova, Dana. 2010

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6. From the Cover: Potent CRISPR-Cas9 inhibitors from Staphylococcus genomes [O] . Kyle E. Watters, Haridha Shivram, Christof Fellmann, 2020

机译：从封面：金黄色葡萄球菌基因组的有力CRISPR-Cas9抑制剂
7. CRISPR-Cas9 fusion to dominant-negative 53BP1 enhances HDR and inhibits NHEJ specifically at Cas9 target sites [O] . Rajeswari Jayavaradhan, Devin M. Pillis, Michael Goodman, 2019

机译：CRISPR-CAS9融合到显性负53bp1增强了HDR，并在CAS9靶位站点抑制NHEJ

Potent CRISPR-Cas9 inhibitors fromStaphylococcusgenomes

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