首页> 外文OA文献 >Exposure of Infants to Isoniazid via Breast Milk After Maternal Drug Intake of Recommended Doses Is Clinically Insignificant Irrespective of Metaboliser Status. A Physiologically-Based Pharmacokinetic (PBPK) Modelling Approach to Estimate Drug Exposure of Infants via Breast-Feeding

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Exposure of Infants to Isoniazid via Breast Milk After Maternal Drug Intake of Recommended Doses Is Clinically Insignificant Irrespective of Metaboliser Status. A Physiologically-Based Pharmacokinetic (PBPK) Modelling Approach to Estimate Drug Exposure of Infants via Breast-Feeding

机译：母乳在推荐剂量的母乳摄入后通过母乳暴露于异烟乳的临床上无关紧要。一种基于生理学的药代动力学（PBPK）建模方法，通过母乳喂养估计婴儿的药物暴露

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Estella Dora Germaine Garessus; Hans Mielke; Ursula Gundert-Remy;
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1. Exposure of Infants to Isoniazid via Breast Milk After Maternal Drug Intake of Recommended Doses Is Clinically Insignificant Irrespective of Metaboliser Status. A Physiologically-Based Pharmacokinetic (PBPK) Modelling Approach to Estimate Drug Exposure of Infants via Breast-Feeding [J] . Estella Dora Germaine Garessus, Hans Mielke, Ursula Gundert-Remy Frontiers in Pharmacology . 2019,第8期

机译：母婴摄入推荐剂量的药物后，通过母乳暴露于异烟肼的婴儿与代谢物状态无关，在临床上意义不大。基于生理的药代动力学（PBPK）建模方法，通过母乳喂养估计婴儿的药物暴露
2. Utility of a physiologically-based pharmacokinetic (PBPK) modeling approach to quantitatively predict a complex drug-drug-disease interaction scenario for rivaroxaban during the drug review process: Implications for clinical practice [J] . GrilloJ.A., ZhaoP., BullockJ., Biopharmaceutics and Drug Disposition . 2012,第2期

机译：基于生理学的药代动力学（PBPK）建模方法可在药物审查过程中定量预测利伐沙班的复杂药物-药物-疾病相互作用场景：对临床实践的启示
3. DEVELOPMENT OF AN OPEN-SOURCE PHYSIOLOGICALLY-BASED PHARMACOKINETIC MODEL TO PREDICT MATERNAL-FETAL EXPOSURES OF CYP450-METABOLIZED DRUGS. [J] . Gastonguay M., Russell S., Freling R., Clinical Pharmacology and Therapeutics . 2019,第Suppla1期

机译：开发开源生理学药代动力学模型，以预测CYP450代谢药物的母体胎儿。
4. Structural and bio-molecular interactions in human tenascin C and HIV: An in silico approach to avert AIDS, for infants under the exposure of HIV: Computational approach for avertion of AIDS in infants by breast milk [C] . Sujay Ray, Arundhati Banerjee IEEE International Conference on Research in Computational Intelligence and Communication Networks . 2015

机译：人腱糖蛋白C和HIV中的结构和生物分子相互作用：一种避免感染艾滋病毒的婴儿的计算机方法，可避免艾滋病毒感染：通过母乳平均减少婴儿艾滋病的计算方法
5. Critical determinants of infant drug exposure via the breast milk: Infant systemic clearance and active transport mechanisms across the mammary epithelium. [D] . Alcorn, Mary-Jane. 2002

机译：婴儿通过母乳接触药物的关键决定因素：婴儿的全身清除率和跨乳腺上皮的主动转运机制。
6. Exposure of Infants to Isoniazid via Breast Milk After Maternal Drug Intake of Recommended Doses Is Clinically Insignificant Irrespective of Metaboliser Status. A Physiologically-Based Pharmacokinetic (PBPK) Modelling Approach to Estimate Drug Exposure of Infants via Breast-Feeding [O] . Estella Dora Germaine Garessus, Hans Mielke, Ursula Gundert-Remy -1

机译：母体药物摄入推荐剂量后婴儿通过母乳暴露于异烟肼的临床意义无关紧要与代谢物状态无关。基于生理的药代动力学（PBPK）建模方法通过母乳喂养估计婴儿的药物暴露
7. Pharmacokinetics of toxic chemicals in breast milk: use of PBPK models to predict infant exposure. [O] . Clewell Rebecca A, Gearhart Jeffery M 100

机译：母乳中有毒化学物质的药代动力学：使用PBPK模型预测婴儿的暴露情况。

Exposure of Infants to Isoniazid via Breast Milk After Maternal Drug Intake of Recommended Doses Is Clinically Insignificant Irrespective of Metaboliser Status. A Physiologically-Based Pharmacokinetic (PBPK) Modelling Approach to Estimate Drug Exposure of Infants via Breast-Feeding

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