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Monoclonal antibody 7G3 recognizes the N-terminal domain of the human interleukin-3 (IL-3) receptor alpha-chain and functions as a specific IL-3 receptor antagonist

机译：单克隆抗体7G3识别人白细胞介素-3（IL-3）受体α链的N-末端结构域并用作特定IL-3受体拮抗剂

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Q Sun; JM Woodcock; A Rapoport; FC Stomski; EI Korpelainen; CJ Bagley; GJ Goodall; WB Smith; JR Gamble; MA Vadas; AF Lopez;
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1. Differential regulation of human eosinophil IL-3, IL-5, and GM-CSF receptor alpha-chain expression by cytokines: IL-3, IL-5, and GM-CSF down-regulate IL-5 receptor alpha expression with loss of IL-5 responsiveness, but up-regulate IL-3 receptor alpha [J] . Gregory B, Kirchem A, Phipps S, The Journal of Immunology: Official Journal of the American Association of Immunologists . 2003,第11期

机译：通过细胞因子对人嗜酸性粒细胞IL-3，IL-5和GM-CSF受体α链表达的差异调节：IL-3，IL-5和GM-CSF下调IL-5并伴随IL丢失-5反应性，但上调IL-3受体α
2. Human interleukin-3 (IL-3) induces disulfide-linked IL-3 receptor alpha- and beta-chain heterodimerization, which is required for receptor activation but not high-affinity binding. [J] . F C Stomski, Q Sun, C J Bagley, Molecular and Cellular Biology . 1996,第6期

机译：人白介素3（IL-3）诱导二硫键连接的IL-3受体α和β链异二聚，这是受体激活所必需的，但不是高亲和力结合。
3. Differential Regulation of Human Eosinophil IL-3, IL-5, and GM-CSF Receptor α-Chain Expression by Cytokines: IL-3, IL-5, and GM-CSF Down-Regulate IL-5 Receptor α Expression with Loss of IL-5 Responsiveness, but Up-Regulate IL-3 Receptor α Expression [J] . Bernard Gregory, Antje Kirchem, Simon Phipps, The journal of immunology . 2003,第11期

机译：细胞因子对人嗜酸性粒细胞IL-3，IL-5和GM-CSF受体α链表达的差异调节：IL-3，IL-5和GM-CSF下调IL-5受体α表达而失去IL -5反应性，但上调IL-3受体α表达
4. The Three-Dimensional Structure of the N-Terminal Domain of Corticotropin-Releasing Factor Receptors:Sushi Domains and the B1 Family of G Protein—Coupled Receptors [C] . MARILYN H. PERRIN, CHRISTY R. R. GRACE, ROLAND RIEK, International Symposium on VIP, PACAP, and Related Peptides . 2006

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5. The importance of specific amino acid residues in transmembrane domains 3 and 5 of a corticotropin releasing-factor receptor for functional activity of a CRF-r1 selective small molecule antagonist [D] . Grigoriadis, Christopher E. 2014

机译：促肾上腺皮质激素释放因子受体跨膜结构域3和5中特定氨基酸残基对CRF-r1选择性小分子拮抗剂功能活性的重要性
6. Involvement of the N-terminal region of the human mineralocorticoid receptor hormone-binding domain in agonist and antagonist binding as revealed by a new monoclonal antibody. [O] . S Jalaguier, B Lupo, G Hugon, 1997

机译：如新的单克隆抗体所揭示的人盐皮质激素受体激素结合结构域的N-末端区域参与激动剂和拮抗剂的结合。
7. Monoclonal antibodies specific for low-affinity interleukin-3 (IL-3) binding protein AIC2A: evidence that AIC2A is a component of a high- affinity IL-3 receptor [O] . T Ogorochi, T Hara, HM Wang, 1992

机译：针对低亲和力白细胞介素-3（IL-3）结合蛋白AIC2A的单克隆抗体：AIC2A是高亲和力IL-3受体的组分
8. Use of Monoclonal Antibodies to Study the Structural Basis of the Function of Nicotinic Acetylcholine Receptors on Electric Organ and Muscle and to Determine the Structure of Nicotinic Acetylcholine Receptors on Neurons. [R] . Lindstrom, J. M. 1989

机译：使用单克隆抗体研究烟碱型乙酰胆碱受体在电活动器官和肌肉上的功能结构基础，并确定神经元上烟碱型乙酰胆碱受体的结构。

Monoclonal antibody 7G3 recognizes the N-terminal domain of the human interleukin-3 (IL-3) receptor alpha-chain and functions as a specific IL-3 receptor antagonist

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