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SARS-CoV-2 RBD-Tetanus toxoid conjugate vaccine induces a strong neutralizing immunity in preclinical studies

机译：SARS-COV-2 RBD-Tetanus毒素缀合物疫苗在临床前研究中诱导强烈的中和免疫力

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Yury Valdes-Balbin; Darielys Santana-Mederos; Lauren Quintero; Sonsire Fernández; Laura Rodriguez; Belinda Sanchez Ramirez; Rocmira Perez; Claudia Acosta; Yanira Méndez; Manuel G. Ricardo; Tays Hernandez; Gretchen Bergado; Franciscary Pi; Annet Valdes; Tania Carmenate; Ubel Ramirez; Reinaldo Oliva; Jean-Pierre Soubal; Raine Garrido; Felix Cardoso; Mario Landys; Humberto Gonzalez; Mildrey Farinas; Juliet Enriquez; Enrique Noa; Anamary Suarez; Cheng Fang; Luis A. Espinosa; Yassel Ramos; Luis Javier González; Yanet Climent; Gertrudis Rojas; Ernesto Relova-Hernández; Yanelys Cabrera Infante; Sum Lai Losada; Tammy Boggiano; Eduardo Ojito; Kalet Leon Monzon; Fabrizio Chiodo; Françoise Paquet; Guang-Wu Chen; Daniel G. Rivera; Dagmar Garcia-Rivera; Vicente Verez-Bencomo;
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1. A novel combined Haemophilus influenzae type b-Neisseria meningitidis serogroups C and Y-tetanus-toxoid conjugate vaccine is immunogenic and induces immune memory when co-administered with DTPa-HBV-IPV and conjugate pneumococcal vaccines in infants [J] . Nolan T, Lambert S, Roberton D, Vaccine . 2007,第51期

机译：与DTPa-HBV-IPV和肺炎球菌肺炎球菌疫苗联合使用时，新型B型流感嗜血杆菌脑膜炎奈瑟氏球菌C和Y-破伤风-类毒素结合疫苗具有免疫原性并诱导免疫记忆。
2. Suppression and modulation of cellular and humoral immune responses to Haemophilus influenzae type B (Hib) conjugate vaccine in hib-diphtheria-tetanus toxoids-acellular pertussis combination vaccines: a study in a rat model. [J] . Mawas F, Newman G, Burns S, The Journal of Infectious Diseases . 2005,第1期

机译：在Hib-白喉-破伤风类毒素-无细胞百日咳组合疫苗中抑制和调节针对B型流感嗜血杆菌（Hib）结合疫苗的细胞和体液免疫反应：一项在大鼠模型中的研究。
3. Immune response, antibody persistence, and safety of a single dose of the quadrivalent meningococcal serogroups A, C, W-135, and Y tetanus toxoid conjugate vaccine in adolescents and adults: results of an open, randomised, controlled study [J] . Charissa Borja-Tabora, Cecilia Montalban, Ziad A Memish, BMC Infectious Diseases . 2013,第1期

机译：青少年和成人单剂量四，四，脑膜炎球菌血清群A，C，W-135和Y破伤风类毒素结合疫苗的免疫应答，抗体持久性和安全性：一项开放，随机，对照研究的结果
4. HIV mucosal vaccine: nasal immunization with rBCG-V3Jl induces a long-term V3J1 peptide-specific neutralizing immunity in Thl- and Th2-deficient condition [C] . Hironobu Goto, Takachika Hiroi, Manabu Ynagita, International Symposium on Tonsils and Mucosal Barriers of Upper Airways . 2003

机译：HIV粘膜疫苗：用RBCG-V3JL的鼻免疫诱导TH2缺乏条件下的长期V3J1肽特异性中和免疫
5. Evaluation of Plasmodium falciparum transmission blocking immunity induced by candidate vaccine antigens Pfs25 and Pfs48/45 and naturally induced immune responses in Zambian children. [D] . LeBlanc, Ralph E. 2009

机译：评价候选疫苗抗原Pfs25和Pfs48 / 45诱导的恶性疟原虫传播阻断免疫以及赞比亚儿童的自然诱导的免疫反应。
6. Immune response antibody persistence and safety of a single dose of the quadrivalent meningococcal serogroups A C W-135 and Y tetanus toxoid conjugate vaccine in adolescents and adults: results of an open randomised controlled study [O] . Charissa Borja-Tabora, Cecilia Montalban, Ziad A Memish, 2013

机译：青少年成人单剂量四四脑膜炎球菌血清群ACW-135和Y破伤风类毒素结合疫苗的免疫应答抗体持久性和安全性：一项开放随机对照研究的结果
7. Self-amplifying RNA SARS-CoV-2 lipid nanoparticle vaccine induces equivalent preclinical antibody titers and viral neutralization to recovered COVID-19 patients [O] . Paul F. McKay, Kai Hu, Anna K. Blakney, 2020

机译：自扩增RNA SARS-COV-2脂质纳米颗粒疫苗诱导当量的临床前抗体滴度和病毒中和回收的Covid-19患者

SARS-CoV-2 RBD-Tetanus toxoid conjugate vaccine induces a strong neutralizing immunity in preclinical studies

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