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Keratin - Based materials for biomedical applications

机译:基于角蛋白的生物医学应用材料

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摘要

Keratin constitutes the major component of the feather, hair, hooves, horns, and wool represents a group of biological material having high cysteine content (7–13%) as compared to other structural proteins. Keratin -based biomaterials have been investigated extensively over the past few decades due to their intrinsic biological properties and excellent biocompatibility. Unlike other natural polymers such as starch, collagen, chitosan, the complex three-dimensional structure of keratin requires the use of harsh chemical conditions for their dissolution and extraction. The most commonly used methods for keratin extraction are oxidation, reduction, steam explosion, microbial method, microwave irradiation and use of ionic liquids. Keratin -based materials have been used extensively for various biomedical applications such as drug delivery, wound healing, tissue engineering. This review covers the structure, properties, history of keratin research, methods of extraction and some recent advancements related to the use of keratin derived biomaterials in the form of a 3-D scaffold, films, fibers, and hydrogels.
机译:角蛋白构成了羽毛,头发,蹄,喇叭和羊毛的主要成分,代表了一组具有高胱氨酸含量(7-13%)的生物材料,与其他结构蛋白相比。由于其内在的生物学性质和优异的生物相容性,过去几十年来,在过去的几十年中已经过广泛研究了角膜蛋白的生物材料。与其他天然聚合物如淀粉,胶原蛋白,壳聚糖,角蛋白的复杂的三维结构需要使用苛刻的化学条件来溶解和提取。角蛋白提取最常用的方法是氧化,还原,蒸汽爆炸,微生物方法,微波辐照和离子液体的使用。基于角膜的材料已被广泛用于各种生物医学应用,例如药物递送,伤口愈合,组织工程。本综述涵盖了角蛋白研究的结构,属性,历史,提取方法以及与使用三蛋白,薄膜,纤维和水凝胶的形式使用角蛋白衍生生物材料的一些最新进步。

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