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Substitution of Arg-244 by Cys or Ser in SHV-1 and SHV-5 Î²-lactamases confers resistance to mechanism-based inhibitors and reduces catalytic efficiency of the enzymes

机译：Cys或SER在SHV-1和SHV-5β-内酰胺酶中取代ARG-244赋予对机理抑制剂的抗性，降低酶的催化效率

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Panagiota Giakkoupi; Eva Tzelepi; Nicholas J Legakis; Leonidas S Tzouvelekis;
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年度 1998
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1. Substitution of Arg-244 by Cys or Ser in SHV-1 and SHV-5 beta-lactamases confers resistance to mechanism-based inhibitors and reduces catalytic efficiency of the enzymes [J] . Giakkoupi P., Legakis NJ., Tzouvelekis LS., FEMS Microbiology Letters . 1998,第1期

机译：在SHV-1和SHV-5β-内酰胺酶中被Cys或Ser取代Arg-244赋予对基于机理的抑制剂的抗性并降低了酶的催化效率
2. Aspartic acid for asparagine substitution at position 276 reduces susceptibility to mechanism-based inhibitors in SHV-1 and SHV-5 beta-lactamases. [J] . Giakkoupi P, Tzelepi E, Legakis NJ, The Journal of Antimicrobial Chemotherapy . 1999,第1期

机译：用于在276位进行天冬酰胺取代的天冬氨酸降低了对SHV-1和SHV-5β-内酰胺酶中基于机理的抑制剂的敏感性。
3. Substitutions at position 105 in SHV family β-lactamases decrease catalytic efficiency and cause inhibitor resistance [J] . LiM., ConklinB.C., TaracilaM.A., Antimicrobial agents and chemotherapy. . 2012,第11期

机译：SHV家族β-内酰胺酶105位的取代基降低催化效率并引起抑制剂抗性
4. Substitutions at Position 105 in SHV Family β-Lactamases Decrease Catalytic Efficiency and Cause Inhibitor Resistance [O] . Mei Li, Benjamin C. Conklin, Magdalena A. Taracila, 2012

机译：SHV家族β-内酰胺酶105位的取代基降低催化效率并引起抗药性
5. Substitutions at Position 105 in SHV Family β-Lactamases Decrease Catalytic Efficiency and Cause Inhibitor Resistance [O] . Mei Li, Benjamin C. Conklin, Magdalena A. Taracila, 2012

机译：SHV家族β-内酰胺酶在SHV系列105的取代降低催化效率并引起抑制剂抗性
6. Mammalian Tissue Trypsin-Like Enzymes: Substrate Specificity and InhibitoryPotency of Substituted Isocoumarin Mechanism-Based Inhibitors, Benzamidine Derivatives, and Arginine Fluoroalkyl Ketone Transition-State Inhibitors [R] . Kam, C. M., Hernandez, M. A., Patil, G. S., 1995

机译：哺乳动物组织中的胰蛋白酶样酶：取代异香豆素机制为基础的抑制剂，苯甲脒衍生物的底物特异性和Inhibitorypotency和精氨酸氟烷酮过渡态抑制剂

Substitution of Arg-244 by Cys or Ser in SHV-1 and SHV-5 Î²-lactamases confers resistance to mechanism-based inhibitors and reduces catalytic efficiency of the enzymes

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