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Pharmacodynamic Relationships between Duration of Action of JDTic-like Kappa-Opioid Receptor Antagonists and Their Brain and Plasma Pharmacokinetics in Rats

机译：JDTIC样Kappa-ApioID受体拮抗剂及其脑和血浆药代动力学在大鼠持续时间之间的药效关系

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S. Michael Owens; Gerald T. Pollard; James L. Howard; Timothy R. Fennell; Rodney W. Snyder; F. Ivy Carroll;
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1. Duration of action of a broad range of selective kappa-opioid receptor antagonists is positively correlated with c-Jun N-terminal kinase-1 activation. [J] . Melief EJ, Miyatake M, Carroll FI, Molecular pharmacology. . 2011,第5期

机译：多种选择性κ-阿片受体拮抗剂的作用持续时间与c-Jun N-末端激酶-1激活呈正相关。
2. Oliceridine, a Novel G Protein–Biased Ligand at the μ‐Opioid Receptor, Demonstrates a Predictable Relationship Between Plasma Concentrations and Pain Relief. II: Simulation of Potential Phase 3 Study Designs Using a Pharmacokinetic/Pharmacodynamic Model [J] . Fossler Michael J., Sadler Brian M., Farrell Colm, The Journal of Clinical Pharmacology: Official Journal of the American College of Clinical Pharmacology . 2018,第6期

机译：Oliceridine是μ-ApiOID受体的新型G蛋白质偏置配体，证明了血浆浓度与疼痛缓解之间的可预测关系。 II：使用药代动力学/药效模型的潜在第3研究设计的模拟
3. Oliceridine (TRV130), a Novel G Protein–Biased Ligand at the μ‐Opioid Receptor, Demonstrates a Predictable Relationship Between Plasma Concentrations and Pain Relief. I: Development of a Pharmacokinetic/Pharmacodynamic Model [J] . Fossler Michael J., Sadler Brian M., Farrell Colm, The Journal of Clinical Pharmacology: Official Journal of the American College of Clinical Pharmacology . 2018,第6期

机译：Oliceridine（TRV130）是μ-ApiOID受体的新型G蛋白偏置配体，证明了血浆浓度和疼痛缓解之间的可预测关系。我：制定药代动力学/药效学模型
4. PHARMACOKINETIC / PHARMACODYNAMIC RELATIONSHIPS OF TIAMULIN (DENAGARD ~R) FOR RESPIRATORY INFECTIONS IN PIGS [C] . D.G.S. Burch, U. Klein Congress ofthe International Pig Veterinary Society . 2008

机译：脂蛋素（Denagard〜R）对猪呼吸道感染的药代动力学/药效学相关
5. Antidepressant and anxiolytic-like effects of kappa-opioid receptor antagonists in Wistar Kyoto rats. [D] . Carr, Gregory Vernon. 2009

机译：κ-阿片受体拮抗剂在Wistar Kyoto大鼠中的抗抑郁和抗焦虑作用。
6. Pharmacodynamic Relationships between Duration of Action of JDTic-like Kappa-Opioid Receptor Antagonists and Their Brain and Plasma Pharmacokinetics in Rats [O] . S. Michael Owens, Gerald T. Pollard, James L. Howard, -1

机译：JDTic样κ阿片受体拮抗剂的作用持续时间与其大鼠脑和血浆药代动力学之间的药效关系
7. Studies with abanoquil (UK-52,046) a novel quinoline alpha 1-adrenoceptor antagonist: II. Duration of action, pharmacokinetics and concentration-effect relationships in normotensive subjects. [O] . Schafers, R F, Elliott, H L, Meredith, P A, 1991

机译：用abanoquil（UK-52,046）研究一种新型喹啉α1-肾上腺素受体拮抗剂：II。血压正常受试者的作用持续时间，药代动力学和浓度效应关系。

Pharmacodynamic Relationships between Duration of Action of JDTic-like Kappa-Opioid Receptor Antagonists and Their Brain and Plasma Pharmacokinetics in Rats

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