首页> 外文OA文献 >Topoisomerase I inhibitor, irinotecan, depletes regulatory T cells and up-regulates MHC class I and PD-L1 expression, resulting in a supra-additive antitumor effect when combined with anti-PD-L1 antibodies

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Topoisomerase I inhibitor, irinotecan, depletes regulatory T cells and up-regulates MHC class I and PD-L1 expression, resulting in a supra-additive antitumor effect when combined with anti-PD-L1 antibodies

机译：Topoisomerase I抑制剂，伊立替康，耗尽调节性T细胞和上调MHC I类和PD-L1表达，当与抗PD-L1抗体结合时，导致Supra-添加剂抗肿瘤效果

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Toshiki Iwai; Masamichi Sugimoto; Daiko Wakita; Keigo Yorozu; Mitsue Kurasawa; Kaname Yamamoto;
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1. Upregulation of PD-L1 Expression by Prostaglandin E2 and the Enhancement of IFN-γ by Anti-PD-L1 Antibody Combined With a COX-2 Inhibitor in Mycoplasma bovis Infection [J] . Goto Shinya, Konnai Satoru, Hirano Yuki, Frontiers in Veterinary Science . 2020,第1期

机译：前列腺素E2的PD-L1表达的上调和抗PD-L1抗体的IFN-γ的增强与支原体萎缩症感染的COX-2抑制剂联合
2. Robust Antitumor Effects of Combined Anti-CD4-Depleting Antibody and Anti-PD-1/PD-L1 Immune Checkpoint Antibody Treatment in Mice [J] . Ueha Satoshi, Yokochi Shoji, Ishiwata Yoshiro, Cancer immunology research. . 2015,第6期

机译：抗CD4消耗抗体和抗PD-1 / PD-L1免疫检查点抗体治疗小鼠的鲁棒抗肿瘤效应
3. Histone deacetylase inhibitors up-regulate the expression of cell surface MHC class-I molecules in B16/BL6 cells [J] . Komatsu Y., Hayashi H. The Journal of Antibiotics: An International Journal . 1998,第1期

机译：组蛋白脱乙酰基酶抑制剂上调B16 / BL6细胞中细胞表面MHC I类分子的表达
4. Potent Antitumor Activity of IL-2-Fc Fusion Proteins Through FcyR-Dependent Depletion of Regulatory T-Cells [C] . Rodrigo Vazquez-Lombardi, Claudia Loetsch, Daniela Zinkl, International Molecular Medicine Tri-Conference. . 2016

机译：通过依赖于调节T细胞的Fcγ1-2-Fc融合蛋白的有效抗肿瘤活性
5. Anti-MHC class I antibody-mediated activation of cell proliferation and survival signaling pathways in endothelial cells. [D] . Jindra, Peter Thomas. 2007

机译：抗MHC I类抗体介导的内皮细胞增殖和存活信号通路的激活。
6. Topoisomerase I inhibitor irinotecan depletes regulatory T cells and up-regulates MHC class I and PD-L1 expression resulting in a supra-additive antitumor effect when combined with anti-PD-L1 antibodies [O] . Toshiki Iwai, Masamichi Sugimoto, Daiko Wakita, 2018

机译：拓扑异构酶I抑制剂伊立替康可耗尽调节性T细胞并上调MHC I类和PD-L1表达与抗PD-L1抗体联合使用时可产生超加性抗肿瘤作用
7. Upregulation of PD-L1 Expression by Prostaglandin E2 and the Enhancement of IFN-γ by Anti-PD-L1 Antibody Combined With a COX-2 Inhibitor in Mycoplasma bovis Infection [O] . Shinya Goto, Satoru Konnai, Yuki Hirano, 2020

机译：前列腺素E2的PD-L1表达的上调和抗PD-L1抗体的IFN-γ的增强与支原体萎缩症感染的COX-2抑制剂联合

Topoisomerase I inhibitor, irinotecan, depletes regulatory T cells and up-regulates MHC class I and PD-L1 expression, resulting in a supra-additive antitumor effect when combined with anti-PD-L1 antibodies

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