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Neutralization potency of monoclonal antibodies recognizing dominant and subdominant epitopes on SARS-CoV-2 Spike is impacted by the B.1.1.7 variant

机译：单克隆抗体的中和效力识别SARS-COV-2穗上的显性和次躯体表位受B.1.1.7变体的影响

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Carl Graham; Jeffrey Seow; Isabella Huettner; Hataf Khan; Neophytos Kouphou; Sam Acors; Helena Winstone; Suzanne Pickering; Rui Pedro Galao; Liane Dupont; Maria Jose Lista; Jose M. Jimenez-Guardeño; Adam G. Laing; Yin Wu; Magdalene Joseph; Luke Muir; Marit J. van Gils; Weng M. Ng; Helen M.E. Duyvesteyn; Yuguang Zhao; Thomas A. Bowden; Manu Shankar-Hari; Annachiara Rosa; Peter Cherepanov; Laura E. McCoy; Adrian C. Hayday; Stuart J.D. Neil; Michael H. Malim; Katie J. Doores;
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1. Murine Monoclonal Antibodies against the Receptor Binding Domain of SARS-CoV-2 Neutralize Authentic Wild-Type SARS-CoV-2 as Well as B.1.1.7 and B.1.351 Viruses and Protect In Vivo in a Mouse Model in a Neutralization-Dependent Manner [J] . Fatima Amanat, Shirin Strohmeier, Wen-Hsin Lee, MBio . 2021,第4期

机译：鼠单克隆抗体对受体结合结构域的SARS-COV-2中和正宗野生型SARS-COV-2以及B.1.1.7和B.1.351病毒，保护<斜体切换=“是”>在体内< /斜体>在鼠标模型中以中和依赖性方式
2. Impact of the N501Y substitution of SARS-CoV-2 Spike on neutralizing monoclonal antibodies targeting diverse epitopes [J] . Lin Cheng, Shuo Song, Bing Zhou, Virology Journal . 2021,第1期

机译：SARS-COV-2 SARS-COV-2穗对靶向不同表位的中和单克隆抗体的影响
3. Characterization of neutralizing monoclonal antibodies recognizing a 15-residues epitope on the spike protein HR2 region of severe acute respiratory syndrome coronavirus (SARS-CoV). [J] . Lai SC, Chong PC, Yeh CT, Journal of biomedical science. . 2005,第5期

机译：识别严重急性呼吸系统综合症冠状病毒（SARS-CoV）的刺突蛋白HR2区域上的15个残基表位的中和单克隆抗体的表征。
4. Identification of Type-Common and Neutralization Epitopes on Hepatitis E Virus Genotype 4 by Using Monoclonal Antibodies [C] . Hongmei Zhang, Xing Dai, Xiangnian Shan, International Forum on Progress on Post-Genome Technologies(5'IFPT); 20070910-11; Suzhou(CN) . 2007

机译：使用单克隆抗体鉴定戊型肝炎病毒基因型4的常见类型和中和表位
5. The potently neutralizing monoclonal antibody 1B7: Its unique epitope, effects on intracellular trafficking, and elicitation upon infection with pertussis. [D] . Sutherland, Jamie Nicole. 2010

机译：强效中和性单克隆抗体1B7：其独特的表位，对细胞内运输有影响，并在感染百日咳后诱发。
6. Bispecific VH/Fab antibodies targeting neutralizing and non-neutralizing Spike epitopes demonstrate enhanced potency against SARS-CoV-2 [O] . Shion A. Lim, Josef A. Gramespacher, Katarina Pance, 2021

机译：靶向中和和非中和尖峰表征的双特异性VH / FAB抗体表现出对SARS-COV-2的增强效力
7. SARS-CoV-2 variant B.1.1.7 is susceptible to neutralizing antibodies elicited by ancestral Spike vaccines [O] . Xiaoying Shen, Haili Tang, Charlene McDanal, 2021

机译：SARS-COV-2变体B.1.1.7易受祖先尖峰疫苗引发的中和抗体的影响
8. Epitope mapping of Ebola virus dominant and subdominant glycoprotein epitopes facilitates construction of an epitope based DNA vaccine able to focus the antibody response in mice. [R] . Schmaljohn, C. 2017

机译：埃博拉病毒显性和次优势糖蛋白表位的表位作图有助于构建能够将抗体反应集中在小鼠中的基于表位的DNa疫苗。

Neutralization potency of monoclonal antibodies recognizing dominant and subdominant epitopes on SARS-CoV-2 Spike is impacted by the B.1.1.7 variant

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