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Protein tyrosine kinase Pyk2 mediates the Jak-dependent activation of MAPK and Stat1 in IFN-γ, but not IFN-α, signaling

机译：蛋白酪氨酸激酶Pyk2在IFN-γ中介导MAPK和Stat1的jak依赖性激活，但不是IFN-α，信号传导

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Akinori Takaoka; Nobuyuki Tanaka; Yukiko Mitani; Tadaaki Miyazaki; Hodaka Fujii; Mitsuharu Sato; Pavel Kovarik; Thomas Decker; Joseph Schlessinger; Tadatsugu Taniguchi;
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1. Caerulomycin A Enhances Transforming Growth Factor-β (TGF-β)-Smad3 Protein Signaling by Suppressing Interferon-γ (IFN-γ)-Signal Transducer and Activator of Transcription 1 (STAT1) Protein Signaling to Expand Regulatory T Cells (Tregs) [J] . Rama Krishna Gurram, Weshely Kujur, Sudeep Maurya, The Journal of biological chemistry . 2014,第25期

机译：Caerucomcin A通过抑制干扰素-γ（IFN-γ） - 转录1（STAT1）蛋白质信号传感器和转录1（STAT1）蛋白信号传递的激活剂来增强转化生长因子-β（TGF-β）-SmAd3蛋白信号传导以扩张调节性T细胞（Tregs）
2. Parafibromin Is a Component of IFN-γ–Triggered Signaling Pathways That Facilitates JAK1/2-Mediated Tyrosine Phosphorylation of STAT1 [J] . Jin Wei, Huan Lian, Bo Zhong, The journal of immunology . 2015,第6期

机译：副纤蛋白是IFN-γ触发信号通路的组成部分，可促进JAK1 / 2介导的STAT1酪氨酸磷酸化。
3. Engagement of cd14 sensitizes primary Monocytes to ifn-γ to produce il-12/23p40 and il-23 through p38 Mitogen-Activated protein Kinase and independent of the Janus Kinase/signal transducers and activators of transcription signaling [J] . BlahoianuM.A., RahimiA.A.R., GajanayakaN., Journal of interferon and cytokine research: The official journal of the International Society for Interferon and Cytokine Research . 2013,第8期

机译：cd14的参与通过p38丝裂原活化的蛋白激酶使原代单核细胞对ifn-γ敏感，从而产生il-12 / 23p40和il-23，而与Janus激酶/信号转导子和转录信号激活子无关
4. Activation of Mitogen-activated Protein Kinases and Protein Kinase B/akt Signaling By Oxidative Stress in Vascular Smooth Muscle Cells: involvement in Vascular Pathophysiology [C] . Ashok K. Srivastava, Nihar R. Pandey, Antoine Blanc International Society for Heart Research.Congress . 2004

机译：血管平滑肌细胞氧化应激激活丝裂剂活化蛋白激酶和蛋白激酶B / Akt信号传导：血管病理生理学中的参与
5. Intracellular signaling pathways regulating hepatic apolipoprotein B100 production: Role of mitogen -activated protein kinases (MAPKs) and inhibitor of NFkappaB kinase (IKK)-NFkappaB. [D] . Tsai, Julie Wen-chia. 2009

机译：调节肝载脂蛋白B100产生的细胞内信号传导途径：促分裂原活化蛋白激酶（MAPK）和NFkappBB激酶（IKK）-NFkappaB抑制剂的作用。
6. Protein tyrosine kinase Pyk2 mediates the Jak-dependent activation of MAPK and Stat1 in IFN-gamma but not IFN-alpha signaling. [O] . A Takaoka, N Tanaka, Y Mitani, 1999

机译：蛋白酪氨酸激酶Pyk2介导IFN-γ信号传导中MAPK和Stat1的Jak依赖性激活但不干扰IFN-α信号传导。
7. Inhibition of IFN-γ-Mediated Inducible Nitric Oxide Synthase Induction by the Peroxisome Proliferator-Activated Receptor γ Agonist, 15-Deoxy-Δ12,14-Prostaglandin J2, Involves Inhibition of the Upstream Janus Kinase/STAT1 Signaling Pathway [O] . Ching-Wen Chen, Ying-Hsin Chang, Chin-Ju Tsi, 2003

机译：过氧化物体增殖物激活的受体γ激动剂，15-脱氧-δ12,14-前列腺素J2的IFN-γ介导的诱导型诱导型诱导型诱导型诱导型诱导型诱导型一氧化氮合酶诱导涉及抑制Janus激酶/ Stat1信号通路的抑制

Protein tyrosine kinase Pyk2 mediates the Jak-dependent activation of MAPK and Stat1 in IFN-γ, but not IFN-α, signaling

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