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AB0116 BROMODOMAIN INHIBITOR, I-BET762 INHIBITS PRODUCTION OF PRO-INFLAMMATORY MEDIATORS BY DOWN-REGULATING BROMODOMAIN AS AN EPIGENETIC READER IN RHEUMATOID ARTHRITIS FIBROBLAST-LIKE SYNOVIOCYTES

机译：AB0116溴染色肿瘤抑制剂，I-Bet762通过将菠萝蛋白酶作为表观遗传读数称为类风湿性关节炎成纤维细胞样Synociytes，抑制促炎介质的产生

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Ra Ham Kim; Hyun Jung Yoo; Shin Eui Kang; Ji Soo Park; Seon Uk Kim; Eun Young Lee; Jin Kyun Park; Yeong Wook Song;
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1. Knockdown of sphingosine kinase 1 inhibits the migration and invasion of human rheumatoid arthritis fibroblast-like synoviocytes by down-regulating the PI3K/AKT activation and MMP-2/9 production in vitro [J] . Yuan Hongxia, Yang Pingting, Zhou Dun, Molecular biology reports . 2014,第8期

机译：抑制神经鞘氨醇激酶1通过下调PI3K / AKT激活和体外MMP-2 / 9的产生抑制类风湿关节炎成纤维细胞样滑膜细胞的迁移和侵袭
2. MiRNA-126 expression inhibits IL-23R mediated TNF- or IFN- production in fibroblast-like synoviocytes in a mice model of collagen-induced rheumatoid arthritis (vol 23, pg 607, 2018) [J] . Gao Jie, Kong Ruina, Zhou Xiaoli, Apoptosis: An international journal on programmed cell death . 2019,第3a4期

机译：miRNA-126表达抑制IL-23R介导的胶原蛋白诱导的类风湿性关节炎的小鼠模型中的成纤维细胞样Synociocytes中的IL-23R或IFN-生产（Vol 23，PG 607,2018）
3. MiRNA-126 expression inhibits IL-23R mediated TNF- or IFN- production in fibroblast-like synoviocytes in a mice model of collagen-induced rheumatoid arthritis [J] . Gao Jie, Kong Ruina, Zhou Xiaoli, Apoptosis: An international journal on programmed cell death . 2018,第11a12期

机译：miRNA-126表达抑制IL-23R在胶原诱导的类风湿性关节炎小鼠模型中的成纤维细胞样Synociocytes中介导的IL-23R或IFN-生产
4. ANALYSIS OF THE BROMODOMAIN BRD3 AND ITS INTERACTIONS WITH THE INHIBITOR JQ1 [C] . William B. Smith, Sean R. Marcsisin, Panagis Filippakopoulos, American Society for Mass Spectrometry Conference on Mass Spectrometry and Allied Topics . 2012

机译：溴琼素BRD3分析及其与抑制剂JQ1的相互作用
5. Effects of IL-27 and Uric Acid Crystal on the Activation of Fibroblast-like Synoviocytes, and the Anti-inflammatory Activities of Sinomenine and Liang Miao San on TNF-alpha-activated Fibroblast-like Synoviocytes in Rheumatoid Arthritis. [D] . Chen, Dapeng. 2011

机译：IL-27和尿酸结晶对类风湿关节炎成纤维细胞样滑膜细胞活化以及青藤碱和凉庙散对TNF-α激活的成纤维细胞样滑膜细胞的抗炎活性。
6. MiRNA-126 expression inhibits IL-23R mediated TNF-α or IFN-γ production in fibroblast-like synoviocytes in a mice model of collagen-induced rheumatoid arthritis [O] . Jie Gao, Ruina Kong, Xiaoli Zhou, -1

机译：在胶原诱导的类风湿性关节炎小鼠模型中miRNA-126的表达抑制成纤维样滑膜细胞中IL-23R介导的TNF-α或IFN-γ的产生
7. Down-regulating peroxisome proliferator-activated receptor-gamma coactivator-1beta alleviates the proinflammatory effect of rheumatoid arthritis fibroblast-like synoviocytes through inhibiting extracellular signal-regulated kinase, p38 and nuclear factor-kappaB activation [O] . 2014

机译：下调过氧化物酶体增殖物激活受体-γcoactivator-1beta通过抑制细胞外信号调节激酶，p38和核因子-kappaB的激活，减轻类风湿关节炎成纤维细胞样滑膜细胞的促炎作用。

AB0116 BROMODOMAIN INHIBITOR, I-BET762 INHIBITS PRODUCTION OF PRO-INFLAMMATORY MEDIATORS BY DOWN-REGULATING BROMODOMAIN AS AN EPIGENETIC READER IN RHEUMATOID ARTHRITIS FIBROBLAST-LIKE SYNOVIOCYTES

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